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Review
. 2017 Jul 15:387:27-42.
doi: 10.1016/j.tox.2017.06.008. Epub 2017 Jun 21.

Quantitative structure-skin permeability relationships

Ivanka Tsakovska  1 , Ilza Pajeva  2 , Merilin Al Sharif  3 , Petko Alov  4 , Elena Fioravanzo  5 , Simona Kovarich  6 , Andrew P Worth  7 , Andrea-Nicole Richarz  8 , Chihae Yang  9 , Aleksandra Mostrag-Szlichtyng  10 , Mark T D Cronin  11
Affiliations
Review

Quantitative structure-skin permeability relationships

Ivanka Tsakovska et al. Toxicology. .

Abstract

This paper reviews in silico models currently available for the prediction of skin permeability. A comprehensive discussion on the developed methods is presented, focusing on quantitative structure-permeability relationships. In addition, the mechanistic models and comparative studies that analyse different models are discussed. Limitations and strengths of the different approaches are highlighted together with the emergent issues and perspectives.

Keywords: Dermal absorption; Mathematical modelling; Permeability; QSPR; Skin; Stratum corneum.

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