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Comment
. 2017 Jul 3;114(27):6885-6887.
doi: 10.1073/pnas.1707809114. Epub 2017 Jun 23.

Versatility of presenilin 1

Georgia R Frost  1   2 , Eitan Wong  1 , Yue-Ming Li  3   2   4
Affiliations
Comment

Versatility of presenilin 1

Georgia R Frost et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Dual effects of PS1 on Aβ production. In its traditional role, presenilin, the catalytic subunit of γ-secretase, cleaves βCTF to release Aβ. However, phosphorylation of PS1 at Ser367 promotes autophagic degradation of βCTF, resulting in reduced Aβ levels. Phosphorylation at Ser367 acts as a switch to convert PS1 between an Aβ-producing state and an Aβ-degrading state, underscoring the importance of PS1 in the regulation of Aβ levels.
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