Cloning the sigma2 receptor: Wandering 40 years to find an identity

doi:10.1073/pnas.1708155114

Comment

. 2017 Jul 3;114(27):6888-6890.

doi: 10.1073/pnas.1708155114. Epub 2017 Jun 23.

Cloning the sigma₂ receptor: Wandering 40 years to find an identity

Felix J Kim¹, Gavril W Pasternak²

Affiliations

¹ Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102; pasterng@mskcc.org fkim@drexelmed.edu.
² Department of Neurology, Molecular Pharmacology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065 pasterng@mskcc.org fkim@drexelmed.edu.

PMID: 28645899
PMCID: PMC5502656
DOI: 10.1073/pnas.1708155114

Comment

Cloning the sigma₂ receptor: Wandering 40 years to find an identity

Felix J Kim et al. Proc Natl Acad Sci U S A. 2017.

. 2017 Jul 3;114(27):6888-6890.

doi: 10.1073/pnas.1708155114. Epub 2017 Jun 23.

Authors

Felix J Kim¹, Gavril W Pasternak²

Affiliations

¹ Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102; pasterng@mskcc.org fkim@drexelmed.edu.
² Department of Neurology, Molecular Pharmacology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065 pasterng@mskcc.org fkim@drexelmed.edu.

PMID: 28645899
PMCID: PMC5502656
DOI: 10.1073/pnas.1708155114

No abstract available

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Conflict of interest statement

Conflict of interest statement: G.W.P. declares no conflict of interest. F.J.K. is cofounder of Context Therapeutics.

Figures

**Fig. 1.**
Comparison of predicted topology and crystal structure of the sigma₁ and sigma₂ receptors. (A) Topology model of the sigma₁ receptor. Reproduced from Laurini et al. (26). (B) Space-fill model of the sigma₁ crystal structure with the bound ligand in yellow. Reproduced from Schmidt et al. (5). (C) Topology model of TMEM97/sigma₂ receptor. Reproduced from Alon et al. (6). (D) Question regarding crystal structure of TMEM97/sigma₂ receptor.

See this image and copyright information in PMC

Comment on

Identification of the gene that codes for the σ₂ receptor.
Alon A, Schmidt HR, Wood MD, Sahn JJ, Martin SF, Kruse AC. Alon A, et al. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7160-7165. doi: 10.1073/pnas.1705154114. Epub 2017 May 30. Proc Natl Acad Sci U S A. 2017. PMID: 28559337 Free PMC article.

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References

1. Martin WR, Eades CG, Thompson JA, Huppler RE, Gilbert PE. The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther. 1976;197:517–532. - PubMed
1. Kushner L, Zukin SR, Zukin RS. Characterization of opioid, sigma, and phencyclidine receptors in the neuroblastoma-brain hybrid cell line NCB-20. Mol Pharmacol. 1988;34:689–694. - PubMed
1. Hellewell SB, Bowen WD. A sigma-like binding site in rat pheochromocytoma (PC12) cells: Decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain. Brain Res. 1990;527:244–253. - PubMed
1. Hanner M, et al. Purification, molecular cloning, and expression of the mammalian sigma1-binding site. Proc Natl Acad Sci USA. 1996;93:8072–8077. - PMC - PubMed
1. Schmidt HR, et al. Crystal structure of the human sigma receptor. Nature. 2016;532:527–530. - PMC - PubMed

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[1] Martin WR, Eades CG, Thompson JA, Huppler RE, Gilbert PE. The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther. 1976;197:517–532. - PubMed

[2] Martin WR, Eades CG, Thompson JA, Huppler RE, Gilbert PE. The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther. 1976;197:517–532. - PubMed

[3] Kushner L, Zukin SR, Zukin RS. Characterization of opioid, sigma, and phencyclidine receptors in the neuroblastoma-brain hybrid cell line NCB-20. Mol Pharmacol. 1988;34:689–694. - PubMed

[4] Kushner L, Zukin SR, Zukin RS. Characterization of opioid, sigma, and phencyclidine receptors in the neuroblastoma-brain hybrid cell line NCB-20. Mol Pharmacol. 1988;34:689–694. - PubMed

[5] Hellewell SB, Bowen WD. A sigma-like binding site in rat pheochromocytoma (PC12) cells: Decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain. Brain Res. 1990;527:244–253. - PubMed

[6] Hellewell SB, Bowen WD. A sigma-like binding site in rat pheochromocytoma (PC12) cells: Decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain. Brain Res. 1990;527:244–253. - PubMed

[7] Hanner M, et al. Purification, molecular cloning, and expression of the mammalian sigma1-binding site. Proc Natl Acad Sci USA. 1996;93:8072–8077. - PMC - PubMed

[8] Hanner M, et al. Purification, molecular cloning, and expression of the mammalian sigma1-binding site. Proc Natl Acad Sci USA. 1996;93:8072–8077. - PMC - PubMed

[9] Schmidt HR, et al. Crystal structure of the human sigma receptor. Nature. 2016;532:527–530. - PMC - PubMed

[10] Schmidt HR, et al. Crystal structure of the human sigma receptor. Nature. 2016;532:527–530. - PMC - PubMed

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Cloning the sigma₂ receptor: Wandering 40 years to find an identity

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Cloning the sigma₂ receptor: Wandering 40 years to find an identity

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