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Editorial
. 2017 Nov;66(5):1384-1386.
doi: 10.1002/hep.29325. Epub 2017 Sep 29.

Hepatic bile acid uptake in humans and mice: Multiple pathways and expanding potential role for gut-liver signaling

Paul A Dawson  1
Affiliations
Editorial

Hepatic bile acid uptake in humans and mice: Multiple pathways and expanding potential role for gut-liver signaling

Paul A Dawson. Hepatology. 2017 Nov.
No abstract available

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Figures

Fig 1
Fig 1
Working model of the phenotype associated with mouse NTCP deficiency. ASBT, apical sodium-dependent bile acid transporter; BSEP, bile salt export pump; FGF15, fibroblast growth factor-15; OATP, organic anion transporting polypeptide; OST, organic solute transporter; T-BA, taurine-conjugated bile acid.
See this image and copyright information in PMC

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References

    1. Vaz FM, Paulusma CC, Huidekoper H, de Ru M, Lim C, Koster J, et al. Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype. Hepatology. 2015;61:260–267. - PubMed
    1. Deng M, Mao M, Guo L, Chen FP, Wen WR, Song YZ. Clinical and molecular study of a pediatric patient with sodium taurocholate cotransporting polypeptide deficiency. Exp Ther Med. 2016;12:3294–3300. - PMC - PubMed
    1. Van Herpe F, Waterham HR, Adams CJ, Mannens M, Bikker H, Vaz FM, et al. NTCP deficiency and persistently raised bile salts: an adult case. J Inherit Metab Dis. 2017;40:313–315. - PubMed
    1. Ho RH, Leake BF, Roberts RL, Lee W, Kim RB. Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition. J Biol Chem. 2004;279:7213–7222. - PubMed
    1. Peng L, Zhao Q, Li Q, Li M, Li C, Xu T, et al. The p.Ser267Phe variant in SLC10A1 is associated with resistance to chronic hepatitis B. Hepatology. 2015;61:1251–1260. - PubMed

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