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. 2016;2(1):1.
doi: 10.21767/2471-304X.100014. Epub 2016 Apr 10.

Prenatal Omega-3 Supplementation and Eczema Risk among Offspring at Age 36 Months

D Berman  1 , C Clinton  2 , R Limb  3 , E C Somers  4   5 , V Romero  6 , E Mozurkewich  7
Affiliations

Prenatal Omega-3 Supplementation and Eczema Risk among Offspring at Age 36 Months

D Berman et al. Insights Allergy Asthma Bronchitis. 2016.

Abstract

Background: Long-term follow-up was completed in 84 mother-infant pairs of 118 women who completed a randomized controlled trial of prenatal supplementation with EPA- or DHA-rich fish oil or soy oil placebo. The goal of this study was to determine whether prenatal omega-3 fatty acid supplementation protects offspring against development of early childhood allergies.

Methods and findings: Assessment of childhood allergic/atopic disease among offspring at age 36 months was performed by maternal interview using the National Health Interview Survey (NHIS) questions for childhood digestive allergies, wheezing, eczema or skin allergy, and respiratory allergy. Multiple logistic regressions examined the association between prenatal supplementation and childhood outcomes, adjusted for covariates. Eczema was reported in 26/84 (31%) of offspring at age 36 months, and was significantly more prevalent in the omega-3 supplementation groups vs. placebo: EPA 13/31 (41.9%); DHA 10/26 (38.5%); placebo 3/27 (11.1%), p=0.019. Compared to placebo, EPA and DHA were associated with ≥5 times risk of offspring eczema [odds ratios (ORs): EPA 5.8 (95% CI 1.4-23.3); DHA 5.0 (95% CI 1.2-21.0)]. After adjusting for other potential risk factors (race, birth weight, vaginal/Cesarean delivery, and maternal eczema) the magnitudes of association for omega-3 supplementation increased: EPA OR 8.1 (95% CI 1.4-45.6); DHA OR 9.6 (95% CI 1.6-58.5). Maternal eczema was also significantly associated with offspring eczema in the adjusted model: OR 10.8 (95% CI 2.1-54.3).

Conclusion: Contrary to our hypothesis, acids supplementation compared to soy oil was associated with a substantial increase in risk of childhood eczema. This association was not observed on childhood respiratory or digestive outcomes. It is unclear if these findings were driven by unfavorable effects of omega-3s, or whether there may have been unanticipated protective effects of the soy-based placebo with regards to eczema.

Keywords: Allergic diseases; Fatty acids; Hypothesis.

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References

    1. Friedman AH, Morris TL. Allergies and anxiety in children and adolescents: A review of the literature. J Clin Psychol Med Settings. 2006;13:318–331.
    1. National Health Interview Survey. U.S. Department of Health and Human Services; Washington, D.C: 2011.
    1. Vassallo MF, Banerji A, Rudders SA, Clark S, Mullins RJ, et al. Season of birth and food allergy in children. Ann Allergy Asthma Immunol. 2010;104:307–313. - PMC - PubMed
    1. Prescott SL, Dunstan JA. Prenatal fatty acid status and immune development: the pathways and the evidence. Lipids. 2007;42:801–810. - PubMed
    1. Blümer N, Renz H. Consumption of omega3-fatty acids during perinatal life: role in immuno-modulation and allergy prevention. J Perinat Med. 2007;35(Suppl 1):S12–S18. - PubMed

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