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. 2017 Dec;43(12):1853-1855.
doi: 10.1007/s00134-017-4853-6. Epub 2017 Jun 26.

From febrile pancytopenia to hemophagocytic lymphohistiocytosis-associated organ dysfunction

Joseph A Carcillo  1   2 , Bradley Podd  3 , Dennis W Simon  3
Affiliations

From febrile pancytopenia to hemophagocytic lymphohistiocytosis-associated organ dysfunction

Joseph A Carcillo et al. Intensive Care Med. 2017 Dec.
No abstract available

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Figures

Fig. 1
Fig. 1
A hypothetical framework illustrating conditions seen in critically ill patients meeting 5 of 8 hemophagocytic lympho histiocytosis criteria that require consideration for different consultative services and therapeutic approaches. Sepsis-induced MODS has decreased NK cell numbers with normal cytolytic (blue circle) function, decreased CD8 cell numbers, and activated macrophages. Non-malignant lymphoproliferative disorders have normal NK cell numbers without cytolytic activity (white circle), with lymphoproliferation and macrophage activation. Malignant lymphoproliferative (violet circle) disorders have failed cytolytic activity and macrophage activation. Macrophage activation syndrome disorders have normal NK cell numbers with reduced cytolytic activity (light blue circle), decreased suppressor T cells, and activated macrophages. MODS multiple organ dysfunction syndrome, NK natural killer, IVIG intravenous immune globulin, AKI acute kidney injury, HLH hemophagocytic lymphohistiocytosis, EBV Epstein–Barr virus, BMT bone marrow transplantation
See this image and copyright information in PMC

References

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