Prevalence of sexual dimorphism in mammalian phenotypic traits
- PMID: 28650954
- PMCID: PMC5490203
- DOI: 10.1038/ncomms15475
Prevalence of sexual dimorphism in mammalian phenotypic traits
Abstract
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.
Conflict of interest statement
Natasha A. Karp is now an employee of AstraZeneca; however, there are no products in development or marketed products related to this work to declare. The remaining authors declare no competing financial interests.
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- MC_U142684171/MRC_/Medical Research Council/United Kingdom
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