Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jun 7:10:155-165.
doi: 10.2147/IDR.S116229. eCollection 2017.

Current perspective on emergence, diagnosis and drug resistance in Candida auris

Smita Sarma  1 , Shalini Upadhyay  1
Affiliations
Review

Current perspective on emergence, diagnosis and drug resistance in Candida auris

Smita Sarma et al. Infect Drug Resist. .

Abstract

Candida auris is an emerging fungus that presents a serious threat to global health. The organism is difficult to identify using conventional biochemical methods. C. auris has also attracted attention because of its reduced susceptibility to azoles, polyenes, and echinocandins, with a few strains even resistant to all three classes of antifungals. In this review paper we discuss the trends in emergence of C. auris in different parts of the world, associated risk factors, drug resistance, and diagnostic challenges. Strategies for prevention and therapeutic options for such infections is also addressed.

Keywords: Candida haemulonii; Candidemia; drug resistance; outbreak.

PubMed Disclaimer

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
AFLP-derived minimum spanning tree of Candida auris isolates. Notes: AFLP-derived minimum spanning tree of C. auris isolates from the UK compared to those from India, Japan, South Africa, South Korea, and Venezuela isolate. C. hemulonii, C. duobushaemulonii, and C. pseudohaemulonii were included to serve as an outgroup. The branch lengths indicate the similarity between isolates with thick solid lines, thin solid line, thick dashed lines, thin dashed lines, and thin dotted lines. C. auris that came from the same geographic region are clustered together. The figure was based on data from Schelenz et al. Abbreviation: AFLP, amplified fragment length polymorphism.
See this image and copyright information in PMC

References

    1. Arendrup MC, Fuursted K, Gahrn-Hansen B, et al. Seminational surveillance of fungemia in Denmark: notably high rates of fungemia and numbers of isolates with reduced azole susceptibility. J Clin Microbiol. 2005;43(9):4434–4440. - PMC - PubMed
    1. Shao LC, Sheng CQ, Zhang WN. Recent advances in the study of antifungal lead compounds with new chemical scaffolds. Yao Xue Xue Bao. 2007;42:1129–1136. Chinese. - PubMed
    1. Eggimann P, Garbino J, Pittet D. Epidemiology of Candida species infections in critically ill non-immunosuppressed patients. Lancet Infect Dis. 2003;3:685–702. - PubMed
    1. Silva S, Henriques M, Martins A, Oliveira R, Williams D, Azeredo J. Biofilms of non-Candida albicans Candida species: quantification, structure and matrix composition. Med Mycol. 2009;47(7):681–689. - PubMed
    1. Pfaller MA, Andes DR, Diekema DJ, et al. Epidemiology and outcomes of invasive candidiasis due to non-albicans species of Candida in 2,496 patients: data from the Prospective Antifungal Therapy (PATH) Registry 2004–2008. PLoS One. 2014;9(7):e101510. - PMC - PubMed

LinkOut - more resources