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. 2016 Jun;9(2):78-82.
doi: 10.1515/intox-2016-0009. Epub 2017 May 17.

Protective effect of resveratrol against neuronal damage through oxidative stress in cerebral hemisphere of aluminum and fluoride treated rats

Chandra Shakar Reddy Nalagoni  1 , Pratap Reddy Karnati  1
Affiliations

Protective effect of resveratrol against neuronal damage through oxidative stress in cerebral hemisphere of aluminum and fluoride treated rats

Chandra Shakar Reddy Nalagoni et al. Interdiscip Toxicol. 2016 Jun.

Abstract

Aluminum has no defined biological function and it is potentially involved in the pathogenesis of neurodegenerative disorders. Furthermore, the presence of fluoride causes more aluminum to accumulate in the brain, resulting in increased neuronal damage. In recent years, resveratrol through its ameliorative effects was found to be a neuroprotectant. This study reports the protective effects of resveratrol on combined aluminum and fluoride induced neuronal damage through oxidative stress in rats. Protective effects of resveratrol (30 mg/kg b.w) on markers of oxidative stress were determined in rats exposed to aluminum chloride (100 mg/kg b.w) along with sodium fluoride (10 mg/kg b.w) for 8 weeks. The results showed a statistically significant (p<0.05) increase in lipid peroxidation (LPx) as well as a significant (p<0.05) decrease in superoxide dismutase and catalase activity. Enlarged cells, neurofibrillary tangles, and vacuolar spaces showing oxidative stress in the cerebral cortex were also observed in hematoxylin and eosin stained sections in aluminum and fluoride treated rats. Administration of resveratrol along with aluminum + fluoride showed significant reversal of oxidative stress and neuronal damage in rats. Thus resveratrol potentially acts as a neuroprotectant against aluminum chloride + sodium fluoride induced neuronal damage through its anti-oxidant efficacy.

Keywords: aluminium; fluoride; neurodegeneration; oxidative stress; resveratrol.

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Figures

Figure 1
Figure 1
Effect of resveratrol treatment on lipid peroxidation in rats subjected to aluminum chloride along with sodium fluoride treatment. Height of histogram bar represents mean values with error bars showing SE values of 5 animals each. *p<0.05 as compared to Control group and #p<0.05 as compared to AlCl3+NaF treated group.
Figure 2
Figure 2
Effect of resveratrol treatment on superoxide dismutase activity in rats subjected to aluminum chloride along with sodium fluoride treatment. Height of histogram bar represents mean values with error bars showing SE values of 5 animals each. *p<0.05 as compared to Control group and #p<0.05 as compared to AlCl3+NaF treated group.
Figure 3
Figure 3
Effect of resveratrol treatment on catalase activity in rats subjected to aluminum chloride along with sodium fluoride treatment. Height of histogram bar represents mean values with error bars showing SE values of 5 animals each. *p<0.05 as compared to Control group and #p<0.05 as compared to AlCl3+NaF treated group.
Figure 4
Figure 4
AlCl3 + NaF treated group shows the appearance of neurofibrillary tangles, vacuolar spaces around the cells and enlarged cells as a measure of toxicity and their decrease in the AlCl3 + NaF + Resveratrol treated group. In addition, there were no morphological changes in the resveratrol alone treated group as compared to the control group.
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