Precision medicine approach to genetic cardiomyopathy

Abstract

Precision medicine aims to achieve improved survival by strategies that recognize the genetic and phenotypic individuality of patients and stratify treatment accordingly. Genetic cardiomyopathies represent an ideal disease group to fully embark on this concept: they are in total frequent diseases with a marked morbidity and mortality and there is ample knowledge about their predisposing genetic factors and associated functional mechanisms. The current review highlights the genetic etiology and gives examples of the diverse treatment strategies that are envisaged in the future.

Keywords: Arrhythmia; Clustered regularly interspaced short palindromic repeats; Gene repair; Genetic testing; Genome-wide association study; Mutations; Risk assessment; Sudden cardiac death.