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Review
. 2017 Aug 1;56(30):3863-3873.
doi: 10.1021/acs.biochem.7b00536. Epub 2017 Jul 17.

Residue-Specific Peptide Modification: A Chemist's Guide

Justine N deGruyter  1 , Lara R Malins  1 , Phil S Baran  1
Affiliations
Review

Residue-Specific Peptide Modification: A Chemist's Guide

Justine N deGruyter et al. Biochemistry. .

Abstract

Advances in bioconjugation and native protein modification are appearing at a blistering pace, making it increasingly time consuming for practitioners to identify the best chemical method for modifying a specific amino acid residue in a complex setting. The purpose of this perspective is to provide an informative, graphically rich manual highlighting significant advances in the field over the past decade. This guide will help triage candidate methods for peptide alteration and will serve as a starting point for those seeking to solve long-standing challenges.

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Conflict of interest statement

Notes

The authors declare no competing financial interest.

Figures

Scheme 1
Scheme 1
See this image and copyright information in PMC

References

    1. Shenvi RA, O’Malley DP, Baran PS. Chemoselectivity: The mother of invention in total synthesis. Acc Chem Res. 2009;42:530–541. - PMC - PubMed
    1. Craik DJ, Fairlie DP, Liras S, Price D. The future of peptide-based drugs. Chem Biol Drug Des. 2013;81:136–147. - PubMed
    1. Fosgerau K, Hoffmann T. Peptide therapeutics: current status and future directions. Drug Discovery Today. 2015;20:122–128. - PubMed

    1. For recent comprehensive reviews of the field, see refs–

    2. Hermanson GT. Bioconjugate Techniques. 3rd. Academic Press; San Diego: 2013.
    1. Koniev O, Wagner A. Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation. Chem Soc Rev. 2015;44:5495–5551. - PubMed

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