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Editorial
. 2017 Jul;102(7):1137-1138.
doi: 10.3324/haematol.2017.171538.

Antithymocyte globulin and transplants for aplastic anemia

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Editorial

Antithymocyte globulin and transplants for aplastic anemia

Andrea Bacigalupo. Haematologica. 2017 Jul.
No abstract available

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Figures

Figure 1.
Figure 1.
MSD transplants for SAA - EBMT 1999–2009. Survival in patients with acquired aplastic anemia grafted from HLA identical siblings with bone marrow as a stem cell source (left) or with G mobilized peripheral blood (right). A significant survival advanatage is seen, together with less acute and chronic GvHD.HLA: human leukocyte antigen; MSD: matched sibling donor; EBMT: European Group for Blood and Marrow Transplantation; ATG: antithymocyte globulin; aGvHD: acute graft-versus-host disease; cGvHD: chronic graft-versus-host disease.

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References

    1. Kekre N, Ying Zhang, Mei-Jie Zhan, et al. Effect of antithymocyte globulin source on outcomes of bone marrow transplantation for severe aplastic anemia. Haematologica 2017; 102(7):1291–1298. - PMC - PubMed
    1. Scheinberg P, Fischer SH, Li L, et al. Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia. Blood. 2007;109(8):3219–3224. - PMC - PubMed
    1. Feng X, Kajigaya S, Solomou EE, et al. Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro. Blood. 2008;111(7):3675–3683. - PMC - PubMed
    1. Lopez M, Clarkson MR, Albin M, et al. A novel mechanism of action for anti-thymocyte globulin: induction of CD4+CD25+Foxp3+ regulatory T cells. J Am Soc Nephrol. 2006;17(10):2844–2853. - PubMed
    1. Storb R, Thomas ED, Buckner CD, et al. Allogeneic marrow grafting for treatment of aplastic anemia. Blood. 1974;43(2):157–180. - PubMed

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