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. 2017 Jun 15;9(6):257-262.
doi: 10.4251/wjgo.v9.i6.257.

Effects of age on survival and morbidity in gastric cancer patients undergoing gastrectomy

Yoshinori Fujiwara  1 , Shuichi Fukuda  1 , Masanori Tsujie  1 , Hajime Ishikawa  1 , Kotaro Kitani  1 , Keisuke Inoue  1 , Masao Yukawa  1 , Masatoshi Inoue  1
Affiliations

Effects of age on survival and morbidity in gastric cancer patients undergoing gastrectomy

Yoshinori Fujiwara et al. World J Gastrointest Oncol. .

Abstract

Aim: To evaluate clinicopathological features and surgical outcomes of gastric cancer in elderly and non-elderly patients after inverse probability of treatment weighting (IPTW) method using propensity score.

Methods: We enrolled a total of 448 patients with histologically confirmed primary gastric carcinoma who received gastrectomies. Of these, 115 patients were aged > 80 years old (Group A), and 333 patients were aged < 79 years old (Group B). We compared the surgical outcomes and survival of the two groups after IPTW.

Results: Postoperative complications, especially respiratory complications and hospital deaths, were significantly more common in Group A than in Group B (P < 0.05). Overall survival (OS) was significantly lower in Group A patients than in Group B patients. Among the subset of patients who had pathological Stage I disease, OS was significantly lower in Group A (P < 0.05) than Group B, whereas cause-specific survival was almost equal in the two groups. In multivariate analysis, pathological stage, histology, and extent of lymph node dissection were independent prognostic values for OS.

Conclusion: When the gastrectomy was performed in gastric cancer patients, we should recognized high mortality and comorbidities in that of elderly. More extensive lymph node dissection might improve prognoses of elderly gastric cancer patients.

Keywords: Elderly; Gastric cancer; Lymphadenectomy; Morbidity; Mortality; Prognosis; Propensity score matching; Survival.

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Conflict of interest statement

Conflict-of-interest statement: We have no financial relationship to disclose.

Figures

Figure 1
Figure 1
Receiver operating characteristic curve for three years survival (AUC = 0.642, TP = 0.536, FP = 0.248).
Figure 2
Figure 2
Overall survival (A) and cause-specific survival (B) in two aged group after IPTW method. OS and CSS were significantly lower in Group A than Group B (P < 0.05). OS: Overall survival; CSS: Cause-specific survival; IPTW: Inverse probability of treatment weighting.
Figure 3
Figure 3
Overall survival (A) and cause-specific survival (B) by age group among patients with pStage I gastric cancer who underwent gastrectomy. OS was significantly lower significantly lower in Group A than Group B after IPTW method (P < 0.05). OS: Overall survival; CSS: Cause-specific survival; IPTW: Inverse probability of treatment weighting.
Figure 4
Figure 4
Cause-specific survival and overall survival by age group among patients with pStage IV gastric cancer who underwent gastrectomy; after IPTW method. CCS and OS were significantly lower in Group A than Group B (P < 0.05). OS: Overall survival; CSS: Cause-specific survival; IPTW: Inverse probability of treatment weighting..
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References

    1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359–E386. - PubMed
    1. National Cancer Center, Ganjoho jp. Available from: http://ganjoho.jp/public/cancer/stomach/
    1. Coniglio A, Tiberio GA, Busti M, Gaverini G, Baiocchi L, Piardi T, Ronconi M, Giulini SM. Surgical treatment for gastric carcinoma in the elderly. J Surg Oncol. 2004;88:201–205. - PubMed
    1. Eguchi T, Fujii M, Takayama T. Mortality for gastric cancer in elderly patients. J Surg Oncol. 2003;84:132–136. - PubMed
    1. Hanazaki K, Wakabayashi M, Sodeyama H, Miyazawa M, Yokoyama S, Sode Y, Kawamura N, Ohtsuka M, Miyazaki T. Surgery for gastric cancer in patients older than 80 years of age. Hepatogastroenterology. 1998;45:268–275. - PubMed

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