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Review
. 2017 Jun 1:8:44.
doi: 10.4103/ijpvm.IJPVM_413_16. eCollection 2017.

Efficacy of Human Papillomavirus L1 Protein Vaccines (Cervarix and Gardasil) in Reducing the Risk of Cervical Intraepithelial Neoplasia: A Meta-analysis

Mohammad Reza Haghshenas  1 , Tahoora Mousavi  2 , Motahareh Kheradmand  3 , Mahdi Afshari  4 , Mahmood Moosazadeh  3
Affiliations
Review

Efficacy of Human Papillomavirus L1 Protein Vaccines (Cervarix and Gardasil) in Reducing the Risk of Cervical Intraepithelial Neoplasia: A Meta-analysis

Mohammad Reza Haghshenas et al. Int J Prev Med. .

Abstract

Human papillomavirus (HPV) can induce cervical intraepithelial neoplasia (CIN). Vaccination against HPV can play an important role in CIN prevention. This study aims to estimate the efficacy of L1 protein vaccines (Cervarix and Gardasil) in CIN 1, 2, 3 risk reduction using meta-analysis. Relevant articles were identified by two independent researchers searching international databanks. After application of inclusion/exclusion criteria and quality assessment, eligible articles were entered into the final meta-analysis. Inverse variance method and fixed effect model were used to combine the results of the primary studies. The heterogeneity between the results was assessed using Cochrane and I2 indices. Of 11,530 evidence identified during the primary search, three papers were found eligible for meta-analysis, including 7213 participants in the intervention groups and 7170 healthy controls. The efficacy (95% confidence interval) of HPV 6, 11, 16, 18 monovalent and quadrivalent vaccines against CIN 1, CIN 2, and CIN 3 were estimated as of 95% (88-98), 97% (85-99), and 95% (78-99), respectively. This study showed that L1 protein vaccines Cervarix and Gardasil are highly protective vaccines playing an effective role in the prevention of HPV 6, 11, 16, 18 which are responsible for CIN 1, CIN 2, and CIN 3.

Keywords: Cervical intraepithelial neoplasia; efficacy; human papillomavirus; meta-analysis; vaccine.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of study selection
Figure 2
Figure 2
Forest plot for the efficacy of vaccines against cervical intraepithelial neoplasia 1 based on risk ratio
Figure 3
Figure 3
Forest plot for the efficacy of vaccines against cervical intraepithelial neoplasia 3 based on risk ratio
See this image and copyright information in PMC

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