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Practice Guideline
. 2017 Aug;15(8):1704-1707.
doi: 10.1111/jth.13743. Epub 2017 Jun 28.

Proposal for standardized preanalytical and analytical conditions for measuring thrombin generation in hemophilia: communication from the SSC of the ISTH

Y Dargaud  1 , A S Wolberg  2 , E Gray  3 , C Negrier  1 , H C Hemker  4 ; Subcommittee on Factor VIII, Factor IX, and Rare Coagulation Disorders
Affiliations
Practice Guideline

Proposal for standardized preanalytical and analytical conditions for measuring thrombin generation in hemophilia: communication from the SSC of the ISTH

Y Dargaud et al. J Thromb Haemost. 2017 Aug.
No abstract available

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Conflict of interest statement

Disclosure of Conflict of Interests

H. C. Hemker is a consultant to Diagnostica Stago (Asnieres, France).

Figures

Fig. 1
Fig. 1
(A) Thrombin generation measured in platelet-rich plasma (PRP) from six healthy volunteers, using tissue factor (TF) 1 pM. Blood samples were obtained by direct venepuncture and from a venous catheter at time 0 and 4 h after catheter introduction. Thrombin generation was significantly higher in samples drawn from catheters compared with direct venipuncture (P = 0.0043; Mann–Whitney U-test). (B) Similar experiment in platelet-poor plasma (PPP) from the same volunteers using TF 1 pM and phospholipids 4 μM. Thrombin generation was not significantly different in samples drawn from catheters compared with direct venipuncture (P > 0.05; Mann–Whitney U-test). ETP, endogenous thrombin potential.
See this image and copyright information in PMC

References

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