Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Apr;1(2):112-116.
doi: 10.1093/ndtplus/sfn006. Epub 2008 Feb 14.

Tubulointerstitial nephritis and uveitis (TINU) syndrome: epidemiology, diagnosis and management

Kim T Sinnamon  1 , Aisling E Courtney  2 , Camille Harron  1 , Declan M O'Rourke  3 , Robert N Mullan  1
Affiliations

Tubulointerstitial nephritis and uveitis (TINU) syndrome: epidemiology, diagnosis and management

Kim T Sinnamon et al. NDT Plus. 2008 Apr.
No abstract available

Keywords: corticosteroids; tubulointerstitial nephritis; uveitis.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Renal biopsy specimen showing widespread interstitial inflammation with a predominant mononuclear cell infiltrate (haematoxylin and eosin stain).
Fig. 2
Fig. 2
Improvement in renal function from time of diagnosis. Oral corticosteroid dose was tapered from 60 mg daily to zero by 44 weeks.
Fig. 3
Fig. 3
Graph with superimposed trend lines representing the ongoing improvement in renal function (eGFR was calculated by the four-variable MDRD equation) in three cases of TINU (represented by three differing symbols) over a prolonged period of time. This improvement continued after withdrawal of oral corticosteroids (mean corticosteroid duration = 19 weeks; range 17–23 weeks).
See this image and copyright information in PMC

References

    1. Clarkson MR, Giblin L, O’Connell FP, et al. Acute interstitial nephritis: clinical features and response to corticoid steroid therapy. Nephrol Dial Transplant. 2004;19:2778–2783. - PubMed
    1. Baker RJ, Pusey CD. The changing profile of acute tubulointerstitial nephritis. Nephrol Dial Transplant. 2004;19:8–11. - PubMed
    1. Dobrin RS, Vernier RL, Fish AL. Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis. A new syndrome. Am J Med. 1975;59:325–333. - PubMed
    1. Mandeville JTH, Levinson RD, Holland GN. The tubulointerstitial nephritis and uveitis syndrome. Surv Ophthalmol. 2001;46:195–208. - PubMed
    1. Sessa A, Meroni M, Battini G, et al. Acute renal failure due to idiopathic tubulo-interstitial nephritis and uveitis; ‘TINU syndrome’. Case report and review of the literature. J Nephrol. 2000;13:377–380. - PubMed

LinkOut - more resources