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. 2017 Jul 21;19(14):3747-3750.
doi: 10.1021/acs.orglett.7b01590. Epub 2017 Jun 28.

Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions

Lena Huck  1   2 , Antonio de la Hoz  2 , Angel Díaz-Ortiz  2 , Jesus Alcázar  1
Affiliations

Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions

Lena Huck et al. Org Lett. .

Abstract

An on-demand preparation of organomagnesium reagents is presented using a new flow protocol. The risks associated with the activation of magnesium are circumvented by a new on-column initiation procedure. Required amounts of solutions with a precise titration were obtained. Telescoped flow or batch reactions allow access to a diverse set of functional groups.

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