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. 2017 Dec;61(6):567-574.
doi: 10.1590/2359-3997000000269. Epub 2017 Jun 26.

Circulating omentin-1 might be associated with metabolic health status in different phenotypes of body size

Shahab Alizadeh  1   2 , Khadijeh Mirzaei  3 , Chonur Mohammadi  1   3 , Seyed Ali Keshavarz  4 , Zhila Maghbooli  1
Affiliations

Circulating omentin-1 might be associated with metabolic health status in different phenotypes of body size

Shahab Alizadeh et al. Arch Endocrinol Metab. 2017 Dec.

Abstract

Objective: Adipokines are mediators of body composition and are involved in obesity complications. This study aimed to assess the association of circulating omentin-1, vaspin, and RBP-4 with body composition indices and metabolic health status (MHS) in different phenotypes of body size.

Subjects and methods: A total of 350 subjects were included in the current cross-sectional study. Body composition was measured using a body composition analyzer, and serum concentrations of omentin-1, vaspin, and RBP-4 were assessed by ELISA kits.

Results: Circulating omentin-1 was significantly (OR = 1.81, 95% CI: 1.00-1.91, P = 0.01) and marginally (OR = 1.63, 95%CI: 1.00-1.75, P = 0.06) associated with MHS in the overweight and obese subjects, respectively. But no association was seen between omentin-1 and MHS in normal-weight subjects. Serum levels of vaspin and RBP-4 were not correlated with MHS. Furthermore, a significant positive correlation was observed between circulating omentin-1 and body mass index (BMI) as well as fat percentage (P = 0.02) in the MHS group. Serum vaspin concentrations were not related to body composition components in both groups. In addition, in the MHS group, circulating RBP-4 was positively correlated with fat percentage and fat mass (FM) (p < 0.0001) and was negatively correlated with fat-free mass (FFM) and total body water (TBW) (p < 0.0001). In contrast, in the metabolically unhealthy group, RBP-4 was negatively correlated with fat percentage, FM, and BMI (p < 0.0001) and was positively correlated with FFM and TBW (p < 0.0001).

Conclusions: This study showed that circulating levels of omentin-1 are useful predictors of metabolic health status in overweight and obese people.

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Conflict of interest statement

Disclosure: no potential conflict of interest relevant to this article was reported.

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