doi: 10.1176/ajp.142.11.1334.
Down-regulation of central dopamine receptors in schizophrenia
- PMID: 2865903
- DOI: 10.1176/ajp.142.11.1334
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Down-regulation of central dopamine receptors in schizophrenia
Am J Psychiatry.
1985 Nov.
Abstract
CSF homovanillic acid (HVA) levels reflecting central dopamine release and apomorphine-stimulated human growth hormone (HGH) secretion reflecting central dopamine receptor activity were concomitantly determined in 20 schizophrenic patients. There was a strong negative correlation between HVA and HGH levels: high dopamine release was associated with lower HGH responses to dopamine receptor activation by apomorphine. Studies are reviewed which suggest that the presently observed relationship reflects release-mediated down-regulation of central D2 receptors, the dopamine receptor subtype associated with the antipsychotic properties of neuroleptic medication.
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