Epigenetics make transient states of cancer therapy resistance permanent

Affiliations

Comment

Kristopher Sarosiek. Sci Transl Med. 2017.

. 2017 Jun 28;9(396):eaan6729.

doi: 10.1126/scitranslmed.aan6729.

¹ John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Email: sarosiek@hsph.harvard.edu.

Abstract

Resistance to targeted cancer therapies is mediated by stabilization of transient insensitive states.

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance.
Shaffer SM, Dunagin MC, Torborg SR, Torre EA, Emert B, Krepler C, Beqiri M, Sproesser K, Brafford PA, Xiao M, Eggan E, Anastopoulos IN, Vargas-Garcia CA, Singh A, Nathanson KL, Herlyn M, Raj A. Shaffer SM, et al. Nature. 2017 Jun 15;546(7658):431-435. doi: 10.1038/nature22794. Epub 2017 Jun 7. Nature. 2017. PMID: 28607484 Free PMC article.