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Review
. 2017 Jun 19:12:1177271917715236.
doi: 10.1177/1177271917715236. eCollection 2017.

Making Meaningful Clinical Use of Biomarkers

Matthew J Selleck  1 , Maheswari Senthil  1 , Nathan R Wall  2
Affiliations
Review

Making Meaningful Clinical Use of Biomarkers

Matthew J Selleck et al. Biomark Insights. .

Abstract

This review discusses the current state of biomarker discovery for the purposes of diagnostics and therapeutic monitoring. We underscore relevant challenges that have defined the gap between biomarker discovery and meaningful clinical use. We highlight recent advancements in and propose a way to think about future biomarker development.

Keywords: Biomarkers; diagnostics; liquid biopsy.

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Conflict of interest statement

DECLARATION OF CONFLICTING INTERESTS: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Disclosures and Ethics As a requirement of publication, author(s) have provided to the publisher signed confirmation of compliance with legal and ethical obligations including but not limited to the following: authorship and contributorship, conflicts of interest, privacy and confidentiality, and (where applicable) protection of human and animal research subjects. The authors have read and confirmed their agreement with the ICMJE authorship and conflict of interest criteria. The authors have also confirmed that this article is unique and not under consideration or published in any other publication, and that they have permission from rights holders to reproduce any copyrighted material.

References

    1. Burke HB. Predicting clinical outcomes using molecular biomarkers. Biomark Cancer. 2016;8:89–99. - PMC - PubMed
    1. Tonry CL, Leacy E, Raso C, Finn SP, Armstrong J, Pennington SR. The role of proteomics in biomarker development for improved patient diagnosis and clinical decision making in prostate cancer. Diagnostics (Basel) 2016;6:27. - PMC - PubMed
    1. FDA-NIH Biomarker Working Group . BEST (Biomarkers, EndpointS, and other Tools) Resource. Maryland: Food and Drug Administration-National Institutes of Health Biomarker Working Group; 2016. https://www.ncbi.nlm.nih.gov/pubmed/27010052. - PubMed
    1. Larrea E, Sole C, Manterola L, et al. New concepts in cancer biomarkers: circulating miRNAs in liquid biopsies. Int J Mol Sci. 2016;17:627. - PMC - PubMed
    1. Khan S, Jutzy JM, Aspe JR, McGregor DW, Neidigh JW, Wall NR. Survivin is released from cancer cells via exosomes. Apoptosis. 2011;16:1–12. - PMC - PubMed