Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jul;7(3):166.
doi: 10.1007/s13205-017-0852-0. Epub 2017 Jun 29.

Hypoglycaemic and hypolipidaemic properties of peach gum polysaccharides

Shengjun Wu  1   2   3   4 , Mingsheng Lu  1   2   3   4 , Shujun Wang  5   6   7   8
Affiliations

Hypoglycaemic and hypolipidaemic properties of peach gum polysaccharides

Shengjun Wu et al. 3 Biotech. 2017 Jul.

Abstract

Hyperglycaemia and hyperlipidaemia are major risk factors for coronary artery diseases and atherosclerosis. Peach gum polysaccharides (PGPs) possess various bioactivities. In this study, PGPs were extracted with thermostable α-amylase and investigated in terms of hypolipidaemic and hypoglycaemic activities. KKAy mice were gavaged once daily with either PGPs or distilled water (control group) for 3 weeks. Oral administration of PGPs decreased the levels of serum triglyceride, cholesterol low-density lipoprotein cholesterol, fasting blood glucose, plasma insulin, C-peptide, and HbAlc in mice. Moreover, treatment with PGPs increased the insulin sensitivity index in KKAy mice. Results indicated that PGPs possess significant hypoglycaemic effects and could be developed as a drug for preventing hyperlipidaemia and hyperglycaemia.

Keywords: Hypoglycaemia; Hypolipidaemia; Peach gum; Polysaccharide.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig. 1
Fig. 1
FT-IR spectra of peach gum polysaccharides
Fig. 2
Fig. 2
Ultraviolet visible spectrum of peach gum polysaccharides
See this image and copyright information in PMC

References

    1. Chen TL, Zhang M, Li JL, Surhio MM, Li BB, Ye M. Structural characterization and hypoglycemic activity of Trichosanthes peel polysaccharide LWT-Food. Sci Technol. 2016;70:55–62.
    1. Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabeticpotential. J Ethnopharmacol. 2002;81:81–100. doi: 10.1016/S0378-8741(02)00059-4. - DOI - PubMed
    1. Hou ML. Food analysis. Beijing: Chemical Industry Press; 2004.
    1. Huang M, Wang FQ, Zhou XH, Yang HX, Wang YZ. Hypoglycemic and hypolipidaemic properties of polysaccharides from Enterobacter cloacae Z0206 in KKAy mice. Carbohydr Polym. 2015;117:91–98. doi: 10.1016/j.carbpol.2014.09.008. - DOI - PubMed
    1. Liu W, Zheng Y, Zhang ZZ, Yao WB, Gao XD. Hypoglycemic, hypolipidemic and antioxidant effects of Sarcandra glabra polysaccharide in type 2 diabetic mice. Food Funct. 2014;5:2850–2860. doi: 10.1039/C4FO00430B. - DOI - PubMed

LinkOut - more resources