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Meta-Analysis
. 2017 Jul;15(4):318-324.
doi: 10.2450/2017.0094-17.

The use of fibrinogen concentrate for the management of trauma-related bleeding: a systematic review and meta-analysis

Carlo Mengoli  1 , Massimo Franchini  1   2 , Giuseppe Marano  1 , Simonetta Pupella  1 , Stefania Vaglio  1   3 , Marco Marietta  4 , Giancarlo M Liumbruno  1
Affiliations
Meta-Analysis

The use of fibrinogen concentrate for the management of trauma-related bleeding: a systematic review and meta-analysis

Carlo Mengoli et al. Blood Transfus. 2017 Jul.

Abstract

Haemorrhage following injury is associated with significant morbidity and mortality. The role of fibrinogen concentrate in trauma-induced coagulopathy has been the object of intense research in the last 10 years and has been systematically analysed in this review. A systematic search of the literature identified six retrospective studies and one prospective one, involving 1,650 trauma patients. There were no randomised trials. Meta-analysis showed that fibrinogen concentrate has no effect on overall mortality (risk ratio: 1.07, 95% confidence interval: 0.83-1.38). Although the meta-analytic pooling of the current literature evidence suggests no beneficial effect of fibrinogen concentrate in the setting of severe trauma, the quality of data retrieved was poor and the final results of ongoing randomised trials will help to further elucidate the role of fibrinogen concentrate in traumatic bleeding.

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Conflict of interest statement

Disclosure of conflicts of interest

GML is the Editor-in-Chief of Blood Transfusion and this manuscript has undergone additional external review as a result. The other Authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart of the inclusion of the studies.
Figure 2
Figure 2
Effect of fibrinogen concentrate on overall in-hospital mortality. The effect was measured comparatively as the risk ratio (RR) in three studies amenable to meta-analytical pooling. Squares denote RR, with size proportional to the weight assigned to the study. Horizontal bars indicate 95% confidence intervals (CI) for each study. The diamond represents the aggregate effect, with the width representing the 95% confidence interval of the total effect.
See this image and copyright information in PMC

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