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. 2017 Dec;37(6):458-466.
doi: 10.14639/0392-100X-1246.

Prognostic factors in head and neck cancer: a 10-year retrospective analysis in a single-institution in Italy

G Cadoni  1 , L Giraldi  2 , L Petrelli  1 , M Pandolfini  1 , M Giuliani  1 , G Paludetti  1 , R Pastorino  2 , E Leoncini  2 , D Arzani  2 , G Almadori  1 , S Boccia  3
Affiliations

Prognostic factors in head and neck cancer: a 10-year retrospective analysis in a single-institution in Italy

G Cadoni et al. Acta Otorhinolaryngol Ital. 2017 Dec.

Abstract
in English, Italian

This study was undertaken to evaluate the association between demographics, lifestyle habits, and clinical data and overall survival (OS), recurrence and second primary cancer (SPC) in patients with first primary head and neck cancer (HNC). We retrospectively reviewed data from 482 patients treated at the "Agostino Gemelli" Teaching Hospital, Rome, between 2002-2012 for primary HNC. Individual parameters were evaluated for association with specific outcomes such as OS, cancer recurrence and second primary cancer (SPC) appearance using hazard ratios (HR) and 95% confidence intervals (CIs). Five-year OS was 60.6% for all HNC cases, 49.0% for oral cavity, 54.8% for oropharynx, 50.0% for hypopharynx and 63.4% for larynx. Predictors of OS were older age (HR = 1.04; 95% CI: 1.02-1.05) and advanced tumour stage (HR = 2.00; 95% CI: 1.41-2.84). The risk of recurrence was associated with drinking 8-14 drinks per week (HR = 1.73; 95% CI: 1.00-2.97). The risk of developing SPC increased with advanced tumour stage (HR = 2.75; 95% CI: 1.39-5.44) and with smoking for more than 40 years (HR = 3.68; 95% CI: 1.10-12.30). OS differed among HNC sites. Increasing age was an unfavourable predictor of HNC OS. Tumour stage was a prognostic factor both for OS and for risk of developing SPC. Alcohol and tobacco consumption were prognostic factors for recurrence and SPC, respectively.

È stata condotta un’analisi retrospettiva su 482 pazienti con diagnosi di tumore testa-collo arruolati presso l’ ospedale “Agostino Gemelli” di Roma. L’associazione tra fattori demografici, clinici e comportamentali con la overall survival (OS), il rischio di ricorrenza ed il rischio di un secondo tumore primitivo è stata stimata usando gli Hazard Ratio (HR) e gli intervalli di confidenza al 95% (CIs). La OS considerando tutte le sedi tumorali è stata del 60%, mentre considerando le singole sedi tumorali è risultata del 49.0% per il cavo orale, 54.8% per l’orofaringe, 50.0% per l’ipofaringe e 63.4% per la laringe. Un’età avanzata alla diagnosi (HR = 1.04; 95% CI: 1.02-1.05) ed un avanzato stadio del tumore (HR = 2.00; 95% CI: 1.41-2.84) sono risultati fattori significativamente associati con la OS. Il rischio di ricorrenza è risultato associato con il consumo di alcolici (HR = 1.73; 95% CI: 1.00-2.97). Il rischio di sviluppare un secondo tumore primitivo è risutlato associato con uno stadio avanzato del tumore primario (HR = 2.75; 95% CI: 1.39-5.44) e con l’aver fumato per più di 40 anni (HR = 3.68; 95% CI: 1.10-12.30). In conclusione abbiamo notato che la OS differisce tra le sedi tumorali del tumore testa-collo. Lo stadio tumorale è risultato essere associato sia con la OS che con il rischo di sviluppare un secondo tumore primitivo. Il consumo di alcol e di tabacco sono risultati essere fattori prognostici, rispettivamente, per la ricorrenza e per l’insorgenza di un secondo tumore primitivo.

Keywords: Epidemiology; Head and neck cancer; Prognostic factors.

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Figures

Fig. 1.
Fig. 1.
Kaplan-Meier unadjusted overall 5-year survival by head and neckcancer site.
Fig. 2
Fig. 2
Kaplan-Meier unadjusted overall 5-year survival by head and neck cancer site for early stage tumours.
Fig. 3.
Fig. 3.
Kaplan-Meier unadjusted overall 5-year survival by head and neck cancer site for advanced stage tumours.
See this image and copyright information in PMC

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