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. 2017 Aug 8;117(4):485-493.
doi: 10.1038/bjc.2017.194. Epub 2017 Jun 29.

Harmonisation of biobanking standards in endometrial cancer research

M Adishesh  1   2 , A Fyson  2 , S B DeCruze  1 , J Kirwan  1 ; ENITEC Consortium; H M J Werner  3   4 , D K Hapangama  1   2
Affiliations

Harmonisation of biobanking standards in endometrial cancer research

M Adishesh et al. Br J Cancer. .

Abstract

Background: Endometrial cancer is the most common gynaecological cancer and its incidence is predicted to escalate by 50-100% in 2025 with a parallel increase in associated mortality. Variations in the collection, processing and storage of biospecimens can affect the generalisability of the scientific data. We aimed to harmonise the collection of biospecimens, clinical data relevant to endometrial cancer and to develop standard operative procedures for the collection, processing and storage of endometrial cancer biospecimens.

Methods: We designed research tools, which were evaluated and revised through three consensus rounds - to obtain local/regional, national and European consensus. Modified final tools were disseminated to a panel (n=40) representing all stakeholders in endometrial cancer research for consensus generation.

Results: The final consensus demonstrated unanimous agreement with the minimal surgical and patient data collection tools. A high level of agreement was also observed for the other remaining standard tools.

Conclusions: We here present the final versions of the tools, which are freely available and easily accessible to all endometrial cancer researchers. We believe that these tools will facilitate rapid progress in endometrial cancer research, both in future collaborations and in large-scale multicentre studies.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart illustrating our workflow in designing the EC research tools and the method of generating consensus (Endometrial cancer (EC), European Network of Individualised Treatment in Endometrial Cancer (ENITEC), Endometrial Cancer Patient Data Collection Tool (ECPD), Endometrial Cancer Surgical Data Collection Tool (ECSD), Endometrial Cancer Biospecimen Tool (ECBS), standard operating procedure for collection, processing and storage of tissue and fluid for EC research (SOP-ECBS)).
Figure 2
Figure 2
Statistical analysis of Endometrial Cancer Patient Data Collection Tool (ECPD), Endometrial Cancer Surgical Data Collection Tool (ECSD), Endometrial Cancer Biospecimen Tool (ECBS) and standard operating procedure for collection, processing and storage of tissue and fluid for EC research (SOP-ECBS) tools.
See this image and copyright information in PMC

References

    1. Assfalg M, Bertini I, Colangiuli D, Luchinat C, Schäfer H, Schütz B, Spraul M (2008) Evidence of different metabolic phenotypes in humans. Proc Natl Acad Sci USA 105(5): 1420–1424. - PMC - PubMed
    1. Beral V, Bull D, Reeves G Collaborators MWS (2005) Endometrial cancer and hormone-replacement therapy in the Million Women Study. Lancet 365(9470): 1543–1551. - PubMed
    1. Bergman L, Beelen ML, Gallee MP, Hollema H, Benraadt J, van Leeuwen FE (2000) Risk and prognosis of endometrial cancer after tamoxifen for breast cancer. Comprehensive Cancer Centres’ ALERT Group. Assessment of Liver and Endometrial cancer Risk following Tamoxifen. Lancet 356(9233): 881–887. - PubMed
    1. Bernini P, Bertini I, Luchinat C, Nepi S, Saccenti E, Schäfer H, Schütz B, Spraul M, Tenori L (2009) Individual human phenotypes in metabolic space and time. J Proteome Res 8(9): 4264–4271. - PubMed
    1. Boilesen AE, Bisgaard ML, Bernstein I (2008) Risk of gynecologic cancers in Danish hereditary non-polyposis colorectal cancer families. Acta Obstet Gynecol Scand 87(11): 1129–1135. - PubMed

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