Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Dec;82(23):8134-8.
doi: 10.1073/pnas.82.23.8134.

Suppression of IgE secretion from hybridoma cells in allotype congenic mice: suppression of allotype 7a by T cells in allotype b mice

S Maekawa, C de Szalay, Z Ovary

Suppression of IgE secretion from hybridoma cells in allotype congenic mice: suppression of allotype 7a by T cells in allotype b mice

S Maekawa et al. Proc Natl Acad Sci U S A. 1985 Dec.

Abstract

Anti-2,4-dinitrophenyl (DNP) IgE producing hybridoma B 53 when injected subcutaneously is established equally well in syngeneic BALB/c (heavy-chain allotype a) and congenic CB20 (heavy-chain allotype b) mice. However, secretion of anti-DNP IgE monoclonal antibody is greatly suppressed in CB20 mice. B 53 cells taken from the subcutaneous tumors of CB20 mice produce anti-DNP IgE in vivo in BALB/c mice and in vitro. No difference was observed in IgE production between these cells and the controls taken from BALB/c mice. The suppression of IgE production was due to T cells and/or their product(s) of CB20 mice.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Eur J Immunol. 1978 Aug;8(8):562-8 - PubMed
    1. Nature. 1976 Jan 29;259(5541):313-5 - PubMed
    1. J Exp Med. 1980 Oct 1;152(4):969-78 - PubMed
    1. J Immunol Methods. 1980;37(1):83-8 - PubMed
    1. J Exp Med. 1981 Aug 1;154(2):480-90 - PubMed

Publication types

LinkOut - more resources