Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jul;28(5):1136-1141.
doi: 10.1097/SCS.0000000000003893.

The Role of Skeletal Stem Cells in the Reconstruction of Bone Defects

Matthew P Murphy  1 , Dre Irizarry, Michael Lopez, Alessandra L Moore, Ryan C Ransom, Michael T Longaker, Derek C Wan, Charles K F Chan
Affiliations
Review

The Role of Skeletal Stem Cells in the Reconstruction of Bone Defects

Matthew P Murphy et al. J Craniofac Surg. 2017 Jul.

Abstract

Craniofacial surgery, since its inauguration, has been the culmination of collaborative efforts to solve complex congenital, dysplastic, oncological, and traumatic cranial bone defects. Now, 50 years on from the first craniofacial meeting, the collaborative efforts between surgeons, scientists, and bioengineers are further advancing craniofacial surgery with new discoveries in tissue regeneration. Recent advances in regenerative medicine and stem cell biology have transformed the authors' understanding of bone healing, the role of stem cells governing bone healing, and the effects of the niche environment and extracellular matrix on stem cell fate. This review aims at summarizing the advances within each of these fields.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest.

References

    1. Waterhouse N The history of craniofacial surgery. Facial Plast Surg 1993;9:143–150 - PubMed
    1. Rodby KA, Turin S, Jacobs RJ, et al. Advances in oncologic head and neck reconstruction: systematic review and future considerations of virtual surgical planning and computer aided design/computer aided modeling. J Plast Reconstr Aesthet Surg 2014;67:1171–1185 - PubMed
    1. Levine JP, Patel A, Saadeh PB, et al. Computer-aided design and manufacturing in craniomaxillofacial surgery: the new state of the art. J Craniofac Surg 2012;23:288–293 - PubMed
    1. Kwan MD, Longaker MT. Advances in science and technology: impact on craniofacial surgery. J Craniofac Surg 2008;19:1136–1139 - PubMed
    1. Tevlin R, Seo EY, Marecic O, et al. Pharmacological rescue of diabetic skeletal stem cell niches. Sci Transl Med 2017;9(372). pii: eaag2809. - PMC - PubMed