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. 2017 Oct;101(10):e326-e327.
doi: 10.1097/TP.0000000000001868.

The Use of Ex Vivo Generated Regulatory T-Cell Preparations in a Canine Lung Allograft Model

Kraig V Abrams  1 , Billanna Hwang, Richard A Nash, George E Georges, Wayne Lamm, Barry Storer, David K Madtes, Robert Glenny, Michael S Mulligan
Affiliations

The Use of Ex Vivo Generated Regulatory T-Cell Preparations in a Canine Lung Allograft Model

Kraig V Abrams et al. Transplantation. 2017 Oct.
No abstract available

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Conflict of interest statement

Authorship:

  1. V. Kraig Abrams drafted and revised the manuscript, conducted the studies, analyzed and interpreted the data. No potential conflicts of interest.

  2. Billanna Hwang conducted the studies, analyzed and interpreted the data, and revised the manuscript. No potential conflicts of interest.

  3. Richard A. Nash codesigned the experiment, supervised the studies, interpreted the data, and revised the manuscript. No potential conflicts of interest.

  4. George E. Georges codesigned the experiment. No potential conflicts of interest.

  5. Wayne Lamm performed the pulmonary function tests and interpreted the data. No potential conflicts of interest.

  6. Barry Storer provided statistical support. No potential conflicts of interest.

  7. David K. Madtes participated in the lung transplants, revised the manuscript and interpreted the data. No potential conflicts of interest.

  8. Robb Glenny revised the manuscript and interpreted the data. No potential conflicts of interest.

  9. Michael S Mulligan performed the lung transplants and revised the manuscript. No potential conflicts of interest.

References

    1. Nash RA, Yunusov M, Abrams VK, et al. Immunomodulatory effects of mixed hematopoietic chimerism: immune tolerance in canine model of lung transplantation. Am J Transplant. 2009;9(5):1037–1047. - PMC - PubMed
    1. Farivar AS, Yunusov MY, Chen P, et al. Optimizing a canine survival model of orthotopic lung transplantation. Transplant Proc. 2006;38(5):1638–40. - PubMed
    1. Steiner D, Brunicki N, Blazar BR, Bachar-Lustig E, Reisner Y. Tolerance induction by third-party “off-the-shelf” CD4+CD25+ Treg cells. Exp Hematol. 2006;34(1):66–71. - PubMed
    1. Abrams VK, Hwang B, Lesnikova M, et al. A novel monoclonal antibody specific for canine CD25 (P4A10): selection and evaluation of canine Tregs. Vet Immunol Immunopathol. 2010;135(3–4):257–65. - PMC - PubMed
    1. Koenen HJPM, Joosten I. Antigen-specific regulatory T-cells subsets in transplantation tolerance: regulatory T-cell subset quality reduces the need for quantity. Hum Immunol. 2006;67(9):665–675. - PubMed

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