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Comment
. 2017 Jun 29;170(1):12-14.
doi: 10.1016/j.cell.2017.06.024.

A New Drug Target for Type 2 Diabetes

Lukas K J Stadler  1 , I Sadaf Farooqi  2
Affiliations
Free article
Comment

A New Drug Target for Type 2 Diabetes

Lukas K J Stadler et al. Cell. .
Free article

Abstract

Genetic studies can identify novel therapeutic targets for common complex diseases. In this issue of Cell, Rusu et al. demonstrate that a cluster of genetic variants associated with an increased risk of type 2 diabetes affect the function of a monocarboxylate transporter involved in nutrient flux and hepatic lipid metabolism.

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Comment on

  • Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.
    Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, Carr SA, Wagner BK, Schenone M, Ng MCY, Chen BH; MEDIA Consortium; SIGMA T2D Consortium; Centeno-Cruz F, Zerrweck C, Orozco L, Altshuler DM, Schreiber SL, Florez JC, Jacobs SBR, Lander ES. Rusu V, et al. Cell. 2017 Jun 29;170(1):199-212.e20. doi: 10.1016/j.cell.2017.06.011. Cell. 2017. PMID: 28666119 Free PMC article.

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