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. 2017 Dec;39(12):686-691.
doi: 10.1055/s-0037-1604065. Epub 2017 Jun 30.

Is Pethidine Safe during Labor? Systematic Review

Rogevando Rodrigues Nunes  1 , Paulo Giordano Baima Colares  2 , Juliana Pinto Montenegro  3
Affiliations

Is Pethidine Safe during Labor? Systematic Review

Rogevando Rodrigues Nunes et al. Rev Bras Ginecol Obstet. 2017 Dec.

Abstract
in English, Portuguese

Purpose To verify if pethidine is safe for the conceptus when used during labor. Methods Systematic review in the Capes Periodicals/PubMed and MEDLINE/Virtual Health Library (BVS, in the Portuguese acronym) databases. Results A total of 17 studies published from January 1st, 2000, to September 2nd, 2016, with a total of 1,688 participants involved were included in the present review. There was no record of conceptus vitality decrease associated with low doses of pethidine being administered to mothers during labor. Conclusions Intramuscular (IM) or intravenous (IV) pethidine at low doses, of up to 50 mg, is safe to administer during labor.

Objetivo Verificar se a petidina é segura para o concepto quando utilizada durante o trabalho de parto. Método Revisão sistemática nas bases de dados dos Periódicos Capes/PubMed e MEDLINE/Biblioteca Virtual em Saúde (BVS). Resultados Um total de 17 estudos, publicados de 1° de janeiro de 2000 a 2 de setembro de 2016, totalizando 1.688 participantes envolvidos, foram incluídos nesta revisão. Não houve registro de depressão na vitalidade dos conceptos com doses baixas de petidina administradas às mães durante o trabalho de parto. Conclusão Petidina intramuscular (IM) ou intravenosa (IV) em baixas doses, de até 50 mg, é segura durante o trabalho de parto.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Fig. 1
Fig. 1
Flow chart of the excluded and selected articles.
See this image and copyright information in PMC

Comment in

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