Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jul;42(7):2071-2076.
doi: 10.1007/s11064-017-2331-8. Epub 2017 Jul 1.

Can Neurochemical Changes of Mood Disorders Explain the Increase Risk of Epilepsy or its Worse Seizure Control?

Andres M Kanner  1
Affiliations
Review

Can Neurochemical Changes of Mood Disorders Explain the Increase Risk of Epilepsy or its Worse Seizure Control?

Andres M Kanner. Neurochem Res. 2017 Jul.

Abstract

The existence of a bidirectional relation between mood disorders and epilepsy has been suggested by six population-based studies. Furthermore, three studies have associated a higher risk of treatment-resistant epilepsy with a history of depression preceding the onset of epilepsy. Common pathogenic mechanisms operant in depression and epilepsy may provide a possible explanation of these observations. This article reviews some of the leading pathogenic mechanisms of depression with respect to potential proconvulsant properties that may provide explanations for these phenomena.

Keywords: Cortisol; GABA; Glutamate; Major depressive disorders; Serotonin; Treatment-resistant epilepsy.

PubMed Disclaimer

References

    1. JAMA Neurol. 2017 May 1;74(5):533-539 - PubMed
    1. Brain. 2008 Aug;131(Pt 8):2071-83 - PubMed
    1. Biol Psychiatry. 2007 Dec 1;62(11):1310-6 - PubMed
    1. Am J Psychiatry. 2003 Mar;160(3):577-9 - PubMed
    1. Epilepsia. 2012 Oct;53(10):1705-12 - PubMed