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Review
. 2017 Oct:13:386-392.
doi: 10.1016/j.redox.2017.06.008. Epub 2017 Jun 22.

Non-alcoholic fatty liver disease, to struggle with the strangle: Oxygen availability in fatty livers

Sarit Anavi  1 , Zecharia Madar  2 , Oren Tirosh  3
Affiliations
Review

Non-alcoholic fatty liver disease, to struggle with the strangle: Oxygen availability in fatty livers

Sarit Anavi et al. Redox Biol. 2017 Oct.

Abstract

Nonalcoholic fatty liver diseases (NAFLD) is one of the most common chronic liver disease in Western countries. Oxygen is a central component of the cellular microenvironment, which participate in the regulation of cell survival, differentiation, functions and energy metabolism. Accordingly, sufficient oxygen supply is an important factor for tissue durability, mainly in highly metabolic tissues, such as the liver. Accumulating evidence from the past few decades provides strong support for the existence of interruptions in oxygen availability in fatty livers. This outcome may be the consequence of both, impaired systemic microcirculation and cellular membrane modifications which occur under steatotic conditions. This review summarizes current knowledge regarding the main factors which can affect oxygen supply in fatty liver.

Keywords: Fatty liver; Inflammation; Nitric oxide; Oxygen.

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Figures

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Graphical abstract
Fig. 1
Fig. 1
Sinusoidal cellular interactions that attenuates oxygen availability within the liver. Such interaction regulates oxygen availability During the different stages of the non-alcoholic fatty liver disease. Fat infiltration, Inflammation, and fibrosis. HSC, hepatic stellate cells; ET-1, endothelin-1; Kupffercells; ROS, reactive oxygen species; SEC, sinusoidal endothelial cells.
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