Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2017 Jul;33(7):898-903.
doi: 10.1016/j.cjca.2017.04.011. Epub 2017 May 3.

High-Sensitivity Cardiac Troponin Risk Cutoffs for Acute Cardiac Outcomes at Emergency Department Presentation

Peter A Kavsak  1 , Andrew Worster  2 , Jinhui Ma  3 , Colleen Shortt  4 , Natasha Clayton  5 , Jonathan Sherbino  2 , Stephen A Hill  4 , Matthew McQueen  4 , Shamir R Mehta  6 , Philip J Devereaux  6
Affiliations
Clinical Trial

High-Sensitivity Cardiac Troponin Risk Cutoffs for Acute Cardiac Outcomes at Emergency Department Presentation

Peter A Kavsak et al. Can J Cardiol. 2017 Jul.

Abstract

The optimal high-sensitivity cardiac troponin (hs-cTn) cutoffs for determining risk in patients who present with acute coronary syndrome symptoms are unknown. In 1137 emergency department patients we calculated adjusted relative risks for a composite outcome (myocardial infarction, unstable angina, heart failure, ventricular arrhythmia, or cardiovascular death) within 7 days for the presentation of hs-cTnT (Roche) and hs-cTnI (Abbott) assay concentrations on the basis of literature cutoffs. Patients with hs-cTn concentrations ≥ 14 ng/L had an adjusted relative risk of 4.9 for the composite outcome, with different hs-cTnT/hs-cTnI concentration ranges yielding higher risks. A common low-risk cutoff of 14 ng/L may be used for hs-cTn with higher cutoffs identifying high-risk patients.

Trial registration: ClinicalTrials.gov NCT01994577.

PubMed Disclaimer

Publication types

Associated data

Grants and funding