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Review
. 2017 Sep;38(9):771-793.
doi: 10.1016/j.tips.2017.06.002. Epub 2017 Jun 28.

An Overview of Novel Adjuvants Designed for Improving Vaccine Efficacy

Srinivasa Reddy Bonam  1 , Charalambos D Partidos  2 , Sampath Kumar M Halmuthur  3 , Sylviane Muller  4
Affiliations
Review

An Overview of Novel Adjuvants Designed for Improving Vaccine Efficacy

Srinivasa Reddy Bonam et al. Trends Pharmacol Sci. 2017 Sep.

Abstract

Adjuvants incorporated in prophylactic and/or therapeutic vaccine formulations impact vaccine efficacy by enhancing, modulating, and/or prolonging the immune response. In addition, they reduce antigen concentration and the number of immunizations required for protective efficacy, therefore contributing to making vaccines more cost effective. Our better understanding of the molecular mechanisms of immune recognition and protection has led research efforts to develop new adjuvants that are currently at various stages of development or clinical evaluation. In this review, we focus mainly on several of these promising adjuvants, and summarize recent work conducted in various laboratories to develop novel lipid-containing adjuvants.

Keywords: CpG ODNs; QS-21; delivery systems; lipopeptides; new adjuvants; patents; vaccines.

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