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. 2017 Jul;37(7):3423-3427.
doi: 10.21873/anticanres.11709.

Increased Nicotinamide Phosphoribosyltransferase and Cystathionine-β-Synthase in Renal Oncocytomas, Renal Urothelial Carcinoma, and Renal Clear Cell Carcinoma

Rodney E Shackelford  1 , Jehan Abdulsattar  2 , Eric X Wei  2 , James Cotelingam  2 , Domenico Coppola  3 , Guillermo A Herrera  2
Affiliations

Increased Nicotinamide Phosphoribosyltransferase and Cystathionine-β-Synthase in Renal Oncocytomas, Renal Urothelial Carcinoma, and Renal Clear Cell Carcinoma

Rodney E Shackelford et al. Anticancer Res. 2017 Jul.

Abstract

Background: Renal oncocytomas (ROs), and clear cell (RCC) and urothelial carcinomas (UC), are common renal neoplasms. Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step of NAD+ synthesis and its expression is increased in several tumors. Nampt concomitantly regulates hydrogen sulfide (H2S)-synthesizing enzyme levels, including cystathionine-β-synthase (CBS).

Materials and methods: We used tissue microarrays to examine Nampt and the H2S-synthesizing enzyme CBS protein levels in benign kidney, RCC, UC and ROs.

Results: Compared to benign kidney, all three neoplasms showed increased Nampt and CBS protein levels, with the levels increasing in RCC at higher Fuhrman grades.

Conclusion: H2S is known to ameliorate chronic renal failure but, as yet, no role for H2S in renal neoplasia has been demonstrated. Here, we showed, for the first time, that Nampt, CBS and, likely, H2S likely play a role in malignant and benign neoplastic renal disease.

Keywords: Fuhrman grade; Renal cancer; cystathionine-β-synthase; nicotinamide phosphoribosyltransferase.

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Figures

Figure 1.
Figure 1.
Representative high-power views of Nampt and CBS IHC. Benign renal cortex Nampt (A) and CBS (B). “*” denotes the proximal renal tubule, the arrow the distal renal tubule and “g” the glomerulus. RO Nampt (C) and CBS (D), renal UC Nampt (E) and CBS (F), Fuhrman grade I Nampt (G) and CBS (H), Fuhrman grade II Nampt (I) and CBS (J), Fuhrman grade III Nampt (K) and CBS (L), Fuhrman grade IV Nampt (M) and CBS (N). G through N are RCC. Nampt, Nicotinamide phosphoribosyltransferase; CBS, cystathionine-β-synthase; UC, urothelial carcinoma; RO, renal oncocytoma; IHC, immunohistochemistry.
See this image and copyright information in PMC

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