Impact of Physical Training on Sex Hormones and Their Receptors During N-Methyl- N-nitrosourea-induced Carcinogenesis in Rats
- PMID: 28668849
- DOI: 10.21873/anticanres.11728
Impact of Physical Training on Sex Hormones and Their Receptors During N-Methyl- N-nitrosourea-induced Carcinogenesis in Rats
Abstract
Background/aim: The risk of breast cancer is related to duration of exposure to sex hormones, especially estrogen. The aim of this study was to assess the impact of physical training (PT) on estrogen and progesterone levels and expression of their receptors during carcinogenesis induced by N-methyl-N-nitrosourea (MNU) in rats.
Materials and methods: Fifty female Sprague-Dawley rats were intraperitoneally administered MNU and divided into four groups: low-, moderate-, and high-intensity PT, and no PT (control). Plasma levels of sex hormones and tissue expression of their receptors were quantified and statistically analyzed.
Results: In the group of rats subjected to PT, a significantly higher progesterone level was observed. The highest progesterone level was noted in the low-intensity PT group. An increase in apoptosis of MNU-induced tumor cells was also demonstrated in the PT groups.
Conclusion: PT stimulates apoptosis of tumor cells without an increase in their proliferative activity. The increase in apoptosis of tumor cells correlates positively with the progesterone level.
Keywords: Breast cancer; N-methyl-N-nitrosourea; estrogen; physical training; progesterone.
Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
Similar articles
-
Effect of Physical Training on the Levels of Sex Hormones and the Expression of Their Receptors in Rats With Induced Mammary Cancer in Secondary Prevention Model - Preliminary Study.In Vivo. 2020 Mar-Apr;34(2):495-501. doi: 10.21873/invivo.11800. In Vivo. 2020. PMID: 32111746 Free PMC article.
-
The effect of physical training on the N-methyl-N-nitrosourea-induced mammary carcinogenesis of Sprague-Dawley rats.Exp Biol Med (Maywood). 2015 Nov;240(11):1408-15. doi: 10.1177/1535370215587532. Epub 2015 May 19. Exp Biol Med (Maywood). 2015. PMID: 25990440 Free PMC article.
-
Effects of different durations of estrogen and progesterone treatment on development of N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats.In Vivo. 2006 Nov-Dec;20(6B):829-36. In Vivo. 2006. PMID: 17203775
-
Role of KLF5 in hormonal signaling and breast cancer development.Vitam Horm. 2013;93:213-25. doi: 10.1016/B978-0-12-416673-8.00002-2. Vitam Horm. 2013. PMID: 23810009 Review.
-
Experimental basis for multiple primary carcinogenesis by sex hormones: a review.Cancer. 1977 Oct;40(4 Suppl):1825-32. doi: 10.1002/1097-0142(197710)40:4+<1825::aid-cncr2820400809>3.0.co;2-r. Cancer. 1977. PMID: 332331 Review. No abstract available.
Cited by
-
Carcinogenic Pesticide Control via Hijacking Endosymbiosis; The Paradigm of DSB-A from Wolbachia pipientis for the Management of Otiorhynchus singularis.In Vivo. 2018 Sep-Oct;32(5):1051-1062. doi: 10.21873/invivo.11346. In Vivo. 2018. PMID: 30150426 Free PMC article.
-
Effect of Exercise on Mortality and Recurrence in Patients With Cancer: A Systematic Review and Meta-Analysis.Integr Cancer Ther. 2020 Jan-Dec;19:1534735420917462. doi: 10.1177/1534735420917462. Integr Cancer Ther. 2020. PMID: 32476493 Free PMC article.
-
The Evolution, Functions and Applications of the Breast Cancer Genes BRCA1 and BRCA2.Cancer Genomics Proteomics. 2017 Sep-Oct;14(5):293-298. doi: 10.21873/cgp.20040. Cancer Genomics Proteomics. 2017. PMID: 28870997 Free PMC article. Review.
-
The Influence of Physical Training on the Immune System of Rats during N-methyl-N-nitrosourea-Induced Carcinogenesis.J Clin Med. 2022 Oct 28;11(21):6371. doi: 10.3390/jcm11216371. J Clin Med. 2022. PMID: 36362598 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
