Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Oct;36(8):517-522.
doi: 10.1016/j.eimc.2017.04.007. Epub 2017 Jun 29.

Therapeutic management of Crimean-Congo haemorrhagic fever

[Article in English, Spanish]
Fernando de la Calle-Prieto  1 , Alejandro Martín-Quirós  2 , Elena Trigo  2 , Marta Mora-Rillo  2 , Marta Arsuaga  2 , Marta Díaz-Menéndez  2 , José Ramón Arribas  2
Affiliations
Review

Therapeutic management of Crimean-Congo haemorrhagic fever

[Article in English, Spanish]
Fernando de la Calle-Prieto et al. Enferm Infecc Microbiol Clin (Engl Ed). 2018 Oct.

Abstract
in English, Spanish

Crimean-Congo haemorrhagic fever has been reported in more than 30 countries in Africa, Asia, the Middle East and Eastern Europe, with an increasing incidence in recent years, especially in Europe. Because no specific treatments have demonstrated efficacy, supportive treatment is essential, as well as the provision of a centre with the appropriate means to guarantee the safety of its healthcare professionals. Laboratory monitoring of thrombocytopenia, severe coagulopathy or liver failure is of critical importance. Patients with Crimean-Congo haemorrhagic fever should be admitted to High Level Isolation Units where appropriate biocontainment procedures can prevent nosocomial transmission through infected fluids or accidents with contaminated material. In case of high-risk exposures, early administration of ribavirin should be considered.

La fiebre hemorrágica de Crimea-Congo afecta a más de 30 países de África, Asia, Europa oriental y Oriente Medio, con una creciente incidencia durante los últimos años, especialmente en Europa. Sin un tratamiento específico eficaz, las medidas terapéuticas de soporte son fundamentales, así como disponer de un centro con los medios adecuados para garantizar la seguridad de los trabajadores. La monitorización analítica es esencial para el manejo de la trombocitopenia, la coagulopatía grave o el fallo hepático. La atención a los pacientes con fiebre hemorrágica de Crimea-Congo debe llevarse a cabo en Unidades de Aislamiento de Alto Nivel, capaces de aplicar procedimientos de biocontención que eviten la transmisión nosocomial a través de fluidos infectados o accidentes con material contaminado. En caso de exposiciones de alto riesgo podría plantearse la administración precoz de ribavirina.

Keywords: Antiviral; Antiviral agents; Crimean-Congo haemorrhagic fever; Fiebre hemorrágica de Crimea-Congo; Terapéutica; Therapeutics; Virus; Viruses.

PubMed Disclaimer

References

    1. Brackney D.E., Armstrong P.M. Transmission and evolution of tick-borne viruses. Curr Opin Virol. 2016;21:67–74. - PubMed
    1. Ergönül Ö. Crimean-Congo hemorrhagic fever virus: new outbreaks, new discoveries. Curr Opin Virol. 2012;2:215–220. - PubMed
    1. Estrada-Peña A., Palomar A.M., Santibáñez P., Sánchez N., Habela M.A., Portillo A., et al. Crimean-Congo hemorrhagic fever virus in ticks, southwestern Europe, 2010. Emerg Infect Dis. 2012;18:179–180. - PMC - PubMed
    1. Negredo A., de la Calle-Prieto F., Palencia-Herrejón E., Mora-Rillo M., Astray-Mochales J., Sánchez-Seco M.P., et al. Autochthonous Crimean-Congo hemorrhagic fever in Spain. N Engl J Med. 2017 [in press] - PubMed
    1. Whitehouse C.A. Crimean-Congo hemorrhagic fever. Antiviral Res. 2004;64:145–160. - PubMed

MeSH terms