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Review
. 2017 Jun 16:8:670.
doi: 10.3389/fimmu.2017.00670. eCollection 2017.

What Is the Molecular Signature of Mind-Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices

Ivana Buric  1   2 , Miguel Farias  1 , Jonathan Jong  1 , Christopher Mee  3 , Inti A Brazil  1   2   4   5
Affiliations
Review

What Is the Molecular Signature of Mind-Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices

Ivana Buric et al. Front Immunol. .

Abstract

There is considerable evidence for the effectiveness of mind-body interventions (MBIs) in improving mental and physical health, but the molecular mechanisms of these benefits remain poorly understood. One hypothesis is that MBIs reverse expression of genes involved in inflammatory reactions that are induced by stress. This systematic review was conducted to examine changes in gene expression that occur after MBIs and to explore how these molecular changes are related to health. We searched PubMed throughout September 2016 to look for studies that have used gene expression analysis in MBIs (i.e., mindfulness, yoga, Tai Chi, Qigong, relaxation response, and breath regulation). Due to the limited quantity of studies, we included both clinical and non-clinical samples with any type of research design. Eighteen relevant studies were retrieved and analyzed. Overall, the studies indicate that these practices are associated with a downregulation of nuclear factor kappa B pathway; this is the opposite of the effects of chronic stress on gene expression and suggests that MBI practices may lead to a reduced risk of inflammation-related diseases. However, it is unclear how the effects of MBIs compare to other healthy interventions such as exercise or nutrition due to the small number of available studies. More research is required to be able to understand the effects of MBIs at the molecular level.

Keywords: conserved transcriptional response to adversity; gene expression; inflammation; meditation; mind–body; nuclear factor kappa B; stress; yoga.

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Figures

Figure 1
Figure 1
PRISMA flow chart: the process of selecting relevant studies.
See this image and copyright information in PMC

References

    1. Chiesa A, Serretti A. Mindfulness-based stress reduction for stress management in healthy people: a review and meta-analysis. J Altern Complement Med (2009) 15(5):593–600.10.1089/acm.2008.0495 - DOI - PubMed
    1. Piet J, Hougaard E. The effect of mindfulness-based cognitive therapy for prevention of relapse in recurrent major depressive disorder: a systematic review and meta-analysis. Clin Psychol Rev (2011) 31(6):1032–40.10.1016/j.cpr.2011.05.002 - DOI - PubMed
    1. Strauss C, Cavanagh K, Oliver A, Pettman D. Mindfulness-based interventions for people diagnosed with a current episode of an anxiety or depressive disorder: a meta-analysis of randomised controlled trials. PLoS One (2014) 9(4):e96110.10.1371/journal.pone.0096110 - DOI - PMC - PubMed
    1. Bohlmeijer E, Prenger R, Taal E, Cuijpers P. The effects of mindfulness-based stress reduction therapy on mental health of adults with a chronic medical disease: a meta-analysis. J Psychosom Res (2010) 68(6):539–44.10.1016/j.jpsychores.2009.10.005 - DOI - PubMed
    1. Lazar SW, Kerr CE, Wasserman RH, Gray JR, Greve DN, Treadway MT, et al. Meditation experience is associated with increased cortical thickness. Neuroreport (2005) 16(17):1893–7.10.1097/01.wnr.0000186598.66243.19 - DOI - PMC - PubMed

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