Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jun 16:8:84.
doi: 10.3389/fgene.2017.00084. eCollection 2017.

More Is Better: Recent Progress in Multi-Omics Data Integration Methods

Affiliations
Review

More Is Better: Recent Progress in Multi-Omics Data Integration Methods

Sijia Huang et al. Front Genet. .

Abstract

Multi-omics data integration is one of the major challenges in the era of precision medicine. Considerable work has been done with the advent of high-throughput studies, which have enabled the data access for downstream analyses. To improve the clinical outcome prediction, a gamut of software tools has been developed. This review outlines the progress done in the field of multi-omics integration and comprehensive tools developed so far in this field. Further, we discuss the integration methods to predict patient survival at the end of the review.

Keywords: integration; multi-omics; precision medicine; prediction; prognosis; supervised learning; unsupervised learning.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Unsupervised data integration methodology.
Figure 2
Figure 2
Supervised data integration methodology.

References

    1. Akavia U. D., Litvin O., Kim J., Sanchez-Garcia F., Kotliar D., Causton H. C., et al. . (2010). An integrated approach to uncover drivers of cancer. Cell 143, 1005–1017. 10.1016/j.cell.2010.11.013 - DOI - PMC - PubMed
    1. Aure M. R., Steinfeld I., Baumbusch L. O., Liestøl K., Lipson D., Nyberg S., et al. . (2013). Identifying in-trans process associated genes in breast cancer by integrated analysis of copy number and expression data. PLoS ONE 8:e53014. 10.1371/journal.pone.0053014 - DOI - PMC - PubMed
    1. Bonnet E., Calzone L., Michoel T. (2015). Integrative multi-omics module network inference with Lemon-Tree. PLoS Comput. Biol. 11:e1003983. 10.1371/journal.pcbi.1003983 - DOI - PMC - PubMed
    1. Chari R., Coe B. P., Vucic E. A., Lockwood W. W., Lam W. L. (2010). An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer. BMC Syst. Biol. 4:67. 10.1186/1752-0509-4-67 - DOI - PMC - PubMed
    1. Chen J., Zhang S. (2016). Integrative analysis for identifying joint modular patterns of gene-expression and drug-response data. Bioinformatics 32, 1724–1732. 10.1093/bioinformatics/btw059 - DOI - PubMed