Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jun 25;18(6):1703-1705.
doi: 10.22034/APJCP.2017.18.6.1703.

Age and Gender Related Renal Side Effects of Cisplatin in Animal Model

Zahra Pezeshki  1   2 , Maryam Maleki, Ardeshir Talebi, Mehdi Nematbakhsh
Affiliations

Age and Gender Related Renal Side Effects of Cisplatin in Animal Model

Zahra Pezeshki et al. Asian Pac J Cancer Prev. .

Abstract

Backgrounds: Cisplatin (CDDP) is a choice of anti-cancer drug for cancer chemotherapy with serious side effects such as nephrotoxicity. It seems that age is an important factor influencing the side effects of CDDP. This study was designed to determine the role of age and gender simultaneously in CDDP induced renal toxicity. Methods: 40 Wistar male and female rats were assigned as 6 groups in 3 different age categories (10, 16, and 20 weeks old). The single dose of CDDP (7.5 mg/kg, ip) was administrated, and a week later measurements were performed. Results: Body weight changes in male (not in female) animals aged 16 and 20 weeks were more than 10 weeks old animals (P<0.05). In male rats, the serum levels of creatinine (Cr) and blood urea nitrogen (BUN), and Cr-clearance in aged 10 weeks, normalized kidney weight (KW) in aged 20 weeks, and serum nitrite, aspartate aminotransferase (AST) and malondialdehyde (MDA) levels and kidney tissue damage score (KTDS) in rats aged 16 weeks were significantly altered (P<0.05). Gender difference in serum level of Cr, BUN and nitrite, and Cr-clearance were observed in animals aged10 weeks (P<0.05). Conclusion: The side effects of CDDP are gender depended, and may be different at various ages.

Keywords: Cisplatin; cancer; age; gender; Rat.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The Serum Levels of BUN, Cr, Nitrite, MDA, AST and ALT, and KW and KTDS in the Experimental Groups. * represent for significant difference from other age groups in similar gender (P<0.05) and # represent significant difference from male in similar group (comparison between males and females in each age range) (P<0.05).
See this image and copyright information in PMC

References

    1. Ahmed SB, Fisher NDL, Hollenberg NK. Gender and the renal nitric oxide synthase system in healthy humans. Clin J Am Soc Nephrol. 2007;2:916–31. - PubMed
    1. Aydin I, Agilli M, Aydin FN. Gender differences influence renal injury in cisplatin- treated rats: biochemical evaluation. Biol Trace Elem Res. 2014;158:275. - PubMed
    1. Daniel G, Hahn K, Bravo L, et al. The effect of a single therapeutic dose of cisplatin on GFR in dogs. Oncol Rep. 1997;4:153–6. - PubMed
    1. El-Arabey AA. Gender difference in Cisplatin-induced nephrotoxicity in a rat model. Nephrourol Mon. 2015;7:e23595. - PMC - PubMed
    1. Eshraghi-Jazi F, Nematbakhsh M, Nasri H, et al. The protective role of endogenous nitric oxide donor (L-arginine) in cisplatin-induced nephrotoxicity: Gender related differences in rat model. J Res Med Sci. 2011;16:1389–96. - PMC - PubMed