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. 2017 Dec;177(6):1664-1670.
doi: 10.1111/bjd.15787. Epub 2017 Nov 27.

A genome-wide association study suggests that MAPK14 is associated with diabetic foot ulcers

W Meng  1 , A Veluchamy  1 , H L Hébert  1 , A Campbell  1 , H M Colhoun  2 , C N A Palmer  3
Affiliations

A genome-wide association study suggests that MAPK14 is associated with diabetic foot ulcers

W Meng et al. Br J Dermatol. 2017 Dec.

Abstract

Background: Diabetic foot ulcers (DFUs) are a devastating complication of diabetes.

Objectives: To identify genetic contributors to the development of DFUs in the presence of peripheral neuropathy in a Scottish cohort with diabetes using a genome-wide association study.

Methods: A genome-wide association approach was applied. A case was defined as a person with diabetes (type 1 or type 2) who had ever had a foot ulcer (current or previous) in at least one foot, as well as a positive monofilament test result (i.e. evidence of peripheral neuropathy) recorded in their longitudinal e-health records. A control was defined as an individual with diabetes (type 1 or type 2) who has never been recorded as having a foot ulcer in either foot but who had a positive monofilament test result recorded in either foot in their longitudinal e-health records.

Results: There were 699 DFU cases and 2695 controls in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) dataset. The single-nucleotide polymorphism rs80028505 (Chr6p21·31) in MAPK14 reached genome-wide significance with a lowest P-value of 2·45 × 10-8 . The narrow-sense heritability of this phenotype is 0·06.

Conclusions: We suggest that MAPK14 is associated with DFUs.

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Figures

Figure 1
Figure 1
Workflow of the genome‐wide association study on diabetic foot ulcers (DFUs) in Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS). WTCCC2, Wellcome Trust Case Control Consortium 2; SUMMIT, SUrrogate markers for Micro‐ and Macro‐vascular hard endpoints for Innovative diabetes Tools.
Figure 2
Figure 2
The Manhattan plot of the genome‐wide association study on diabetic foot ulcers (699 cases and 2695 controls). Single‐nucleotide polymorphisms with P‐values > 0·01 were not included. Chr, chromosome.
Figure 3
Figure 3
The regional plot of the MAPK14 region in chromosome 6.
See this image and copyright information in PMC

Comment in

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