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Review
. 2017 Jun 24;6(3):45.
doi: 10.3390/antiox6030045.

Vitamin E and Alzheimer's Disease-Is It Time for Personalized Medicine?

Breana Cervantes  1 , Lynn M Ulatowski  2
Affiliations
Review

Vitamin E and Alzheimer's Disease-Is It Time for Personalized Medicine?

Breana Cervantes et al. Antioxidants (Basel). .

Abstract

For the last two decades, it has been hotly debated whether vitamin E-the major lipid-soluble antioxidant, which functions to maintain neurological integrity-is efficacious as a therapy for Alzheimer's disease. Several factors key to the debate, include (1) which of the eight naturally-occurring vitamin E forms should be used; (2) how combination treatments affect vitamin E efficacy; and (3) safety concerns that most-recently resurfaced after the results of the Selenium and vitamin E Cancer prevention trial SELECT prostate cancer trial. However, with the advent of new genetic technologies and identifications of vitamin E-modulating single nucleotide polymorphisms (SNPs), we propose that clinical trials addressing the question "Is vitamin E an effective treatment for Alzheimer's disease" should consider a more focused and personalized medicine approach to designing experiments. An individual's naturally-occurring SNP variants may indeed influence vitamin E's therapeutic effect on Alzheimer's disease.

Keywords: Alzheimer’s disease; SNPs; oxidative stress; personalized medicine; vitamin E.

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Conflict of interest statement

The authors declare no conflict of interest.

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