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. 2017 Apr 1;111(4):185-187.
doi: 10.1093/trstmh/trx031.

Gastrointestinal tract involvement in melioidosis

Prapit Teparrukkul  1 , Worrarat Kongkasame  1 , Songla Chitsaeng  1 , Gumphol Wongsuwan  2 , Vanaporn Wuthiekanun  2 , Sharon J Peacock  2   3   4 , Direk Limmathurotsakul  2   5   6
Affiliations

Gastrointestinal tract involvement in melioidosis

Prapit Teparrukkul et al. Trans R Soc Trop Med Hyg. .

Abstract

Background: Little is known about the involvement of the human gut in carriage and disease associated with Burkholderia pseudomallei, the cause of melioidosis.

Methods: A hospital-based study was conducted in Northeast Thailand to culture stools or rectal swabs from patients with melioidosis, stools from controls with non-infectious diseases, and gastric biopsies from patients undergoing routine endoscopic investigation.

Results and conclusion: B. pseudomallei was isolated from 9/83 (11%) stools and 9/58 (16%) rectal swabs from 141 patients with melioidosis. All stools from 244 control patients and 799 gastric biopsies from 395 patients with no evidence of melioidosis were culture negative for B. pseudomallei. It is not uncommon for melioidosis patients to shed B. pseudomallei in stool. Colonization of the gut of individuals without signs and symptoms of melioidosis may be rare.

Keywords: Burkholderia pseudomallei; Gastrointestinal tract; Melioidosis.

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References

    1. Limmathurotsakul D, Golding N, Dance DA et al. . Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nat Microbiol 2016;1:15008. - PubMed
    1. Limmathurotsakul D, Kanoksil M, Wuthiekanun V et al. . Activities of daily living associated with acquisition of melioidosis in northeast Thailand: a matched case-control study. PLoS Negl Trop Dis 2013;7(2):e2072. - PMC - PubMed
    1. Limmathurotsakul D, Wongsuvan G, Aanensen D et al. . Melioidosis caused by Burkholderia pseudomallei in drinking water, Thailand, 2012. Emerg Infect Dis 2014;20(2):265–8. - PMC - PubMed
    1. West TE, Myers ND, Limmathurotsakul D et al. . Pathogenicity of high-dose enteral inoculation of Burkholderia pseudomallei to mice. Am J Trop Med Hyg 2010;83(5):1066–9. - PMC - PubMed
    1. Goodyear A, Bielefeldt-Ohmann H, Schweizer H et al. . Persistent gastric colonization with Burkholderia pseudomallei and dissemination from the gastrointestinal tract following mucosal inoculation of mice. PLoS One 2012;7(5):e37324. - PMC - PubMed

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