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Review
. 2017 Aug;35(3):403-408.
doi: 10.1016/j.ncl.2017.03.011. Epub 2017 May 30.

Pathophysiology of Sports-Related Concussion

Kristen Steenerson  1 , Amaal Jilani Starling  2
Affiliations
Review

Pathophysiology of Sports-Related Concussion

Kristen Steenerson et al. Neurol Clin. 2017 Aug.

Abstract

Concussion pathophysiology is complicated and involves numerous mechanisms, including excessive neurotransmitter release, metabolic derangements, neuroinflammation, cerebral blood flow changes, and axonal disruption. The initial biomechanical impact in a concussion results in abnormal function at the cellular level, which initiates a cascade of events that leads to microstructural changes and, in the minority of cases, more persistent, permanent damage.

Keywords: Concussion; TBI; Trauma; Traumatic brain injury.

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