Targeting the Immune System with Pharmacotherapy in Schizophrenia

doi:10.1007/s40501-017-0114-0

. 2017 Jun;4(2):139-151.

doi: 10.1007/s40501-017-0114-0. Epub 2017 Apr 18.

Targeting the Immune System with Pharmacotherapy in Schizophrenia

Jennifer K Melbourne¹, Benjamin Feiner¹, Cherise Rosen¹, Rajiv P Sharma^{1

2}

Affiliations

¹ The Psychiatric Institute, University of Illinois at Chicago, 1601 W. Taylor St., Chicago, IL, USA, 60612.
² Jesse Brown Veterans Affairs Medical Center, 820 South Damen Avenue (M/C 151), Chicago, IL, USA, 60612.

PMID: 28674674
PMCID: PMC5493152
DOI: 10.1007/s40501-017-0114-0

Targeting the Immune System with Pharmacotherapy in Schizophrenia

Jennifer K Melbourne et al. Curr Treat Options Psychiatry. 2017 Jun.

. 2017 Jun;4(2):139-151.

doi: 10.1007/s40501-017-0114-0. Epub 2017 Apr 18.

Authors

Jennifer K Melbourne¹, Benjamin Feiner¹, Cherise Rosen¹, Rajiv P Sharma^{1

2}

Affiliations

¹ The Psychiatric Institute, University of Illinois at Chicago, 1601 W. Taylor St., Chicago, IL, USA, 60612.
² Jesse Brown Veterans Affairs Medical Center, 820 South Damen Avenue (M/C 151), Chicago, IL, USA, 60612.

PMID: 28674674
PMCID: PMC5493152
DOI: 10.1007/s40501-017-0114-0

No abstract available

Keywords: anti-inflammatory; antipsychotics; cytokines; drugs; immune; schizophrenia.

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Conflict of interest statement

Conflict of Interest None of the authors declare any conflicts of interest.

Cited by

Cytokine Imbalance in Schizophrenia. From Research to Clinic: Potential Implications for Treatment.
Reale M, Costantini E, Greig NH. Reale M, et al. Front Psychiatry. 2021 Mar 5;12:536257. doi: 10.3389/fpsyt.2021.536257. eCollection 2021. Front Psychiatry. 2021. PMID: 33746786 Free PMC article. Review.
Cytokine Imbalance as a Biomarker of Treatment-Resistant Schizophrenia.
Shnayder NA, Khasanova AK, Strelnik AI, Al-Zamil M, Otmakhov AP, Neznanov NG, Shipulin GA, Petrova MM, Garganeeva NP, Nasyrova RF. Shnayder NA, et al. Int J Mol Sci. 2022 Sep 26;23(19):11324. doi: 10.3390/ijms231911324. Int J Mol Sci. 2022. PMID: 36232626 Free PMC article. Review.
The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment.
Jansen van Vuren E, Steyn SF, Brink CB, Möller M, Viljoen FP, Harvey BH. Jansen van Vuren E, et al. Biomed Pharmacother. 2021 Mar;135:111200. doi: 10.1016/j.biopha.2020.111200. Epub 2021 Jan 1. Biomed Pharmacother. 2021. PMID: 33421734 Free PMC article. Review.
Treatment with the antipsychotic risperidone is associated with increased M1-like JAK-STAT1 signature gene expression in PBMCs from participants with psychosis and THP-1 monocytes and macrophages.
Melbourne JK, Pang Y, Park MR, Sudhalkar N, Rosen C, Sharma RP. Melbourne JK, et al. Int Immunopharmacol. 2020 Feb;79:106093. doi: 10.1016/j.intimp.2019.106093. Epub 2019 Dec 25. Int Immunopharmacol. 2020. PMID: 31863919 Free PMC article.
The JAK-STAT1 transcriptional signature in peripheral immune cells reveals alterations related to illness duration and acuity in psychosis.
Melbourne JK, Rosen C, Feiner B, Pang Y, Sharma RP. Melbourne JK, et al. Brain Behav Immun. 2019 Mar;77:37-45. doi: 10.1016/j.bbi.2018.11.317. Epub 2018 Nov 29. Brain Behav Immun. 2019. PMID: 30503835 Free PMC article.

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References

1. Hinze-Selch D, Pollmächer T. In vitro cytokine secretion in individuals with schizophrenia: results, confounding factors, and implications for further research. Brain Behav Immun. 2001;15:282–318. - PubMed
1. Goldsmith DR, Rapaport MH, Miller BJ. A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression. Mol Psychiatry. 2016:1–14. The most up to date meta-analysis of peripheral cytokine activity in schizophrenia and related psychiatric illnesses. - PMC - PubMed
1. Upthegrove R, Manzanares-Teson N, Barnes NM. Cytokine function in medication-naive first episode psychosis: A systematic review and meta-analysis. Schizophr Res. 2014;155:101–108. - PubMed
1. Song X-Q, Lv L-X, Li W-Q, Hao Y-H, Zhao J-P. The interaction of nuclear factor-kappa B and cytokines is associated with schizophrenia. Biol Psychiatry. 2009;65:481–488. - PubMed
1. Chase KA, Rosen C, Gin H, Bjorkquist O, Feiner B, Marvin R, Conrin S, Sharma RP. Metabolic and inflammatory genes in schizophrenia. Psychiatry Res. 2015;225:208–11. - PMC - PubMed

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[1] Hinze-Selch D, Pollmächer T. In vitro cytokine secretion in individuals with schizophrenia: results, confounding factors, and implications for further research. Brain Behav Immun. 2001;15:282–318. - PubMed

[2] Hinze-Selch D, Pollmächer T. In vitro cytokine secretion in individuals with schizophrenia: results, confounding factors, and implications for further research. Brain Behav Immun. 2001;15:282–318. - PubMed

[3] Goldsmith DR, Rapaport MH, Miller BJ. A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression. Mol Psychiatry. 2016:1–14. The most up to date meta-analysis of peripheral cytokine activity in schizophrenia and related psychiatric illnesses. - PMC - PubMed

[4] Goldsmith DR, Rapaport MH, Miller BJ. A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression. Mol Psychiatry. 2016:1–14. The most up to date meta-analysis of peripheral cytokine activity in schizophrenia and related psychiatric illnesses. - PMC - PubMed

[5] Upthegrove R, Manzanares-Teson N, Barnes NM. Cytokine function in medication-naive first episode psychosis: A systematic review and meta-analysis. Schizophr Res. 2014;155:101–108. - PubMed

[6] Upthegrove R, Manzanares-Teson N, Barnes NM. Cytokine function in medication-naive first episode psychosis: A systematic review and meta-analysis. Schizophr Res. 2014;155:101–108. - PubMed

[7] Song X-Q, Lv L-X, Li W-Q, Hao Y-H, Zhao J-P. The interaction of nuclear factor-kappa B and cytokines is associated with schizophrenia. Biol Psychiatry. 2009;65:481–488. - PubMed

[8] Song X-Q, Lv L-X, Li W-Q, Hao Y-H, Zhao J-P. The interaction of nuclear factor-kappa B and cytokines is associated with schizophrenia. Biol Psychiatry. 2009;65:481–488. - PubMed

[9] Chase KA, Rosen C, Gin H, Bjorkquist O, Feiner B, Marvin R, Conrin S, Sharma RP. Metabolic and inflammatory genes in schizophrenia. Psychiatry Res. 2015;225:208–11. - PMC - PubMed

[10] Chase KA, Rosen C, Gin H, Bjorkquist O, Feiner B, Marvin R, Conrin S, Sharma RP. Metabolic and inflammatory genes in schizophrenia. Psychiatry Res. 2015;225:208–11. - PMC - PubMed

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Targeting the Immune System with Pharmacotherapy in Schizophrenia

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Targeting the Immune System with Pharmacotherapy in Schizophrenia

Authors

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Conflict of interest statement

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