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. 2017 Jul 13;53(57):8062-8065.
doi: 10.1039/c7cc02057k.

Improving bioassay sensitivity through immobilization of bio-probes onto reactive micelles

Gloria Jiménez-Sánchez  1 , Céline Terrat, Bernard Verrier, Didier Gigmes, Thomas Trimaille
Affiliations

Improving bioassay sensitivity through immobilization of bio-probes onto reactive micelles

Gloria Jiménez-Sánchez et al. Chem Commun (Camb). .

Abstract

An antigen probe (HIV-1 p24) immobilized onto N-succinimidyl ester based micelles was used as a solid phase coating in ELISA test, and induced a significant improvement in antibody detection sensitivity as compared to the standard free antigen coating. The relevance of this straightforward approach to improve the bioassay sensitivity was confirmed by using biotin as a generic probe.

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