Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Sep;11(5):418-424.
doi: 10.1111/irv.12461. Epub 2017 Jul 26.

Predictors for fatal human infections with avian H7N9 influenza, evidence from four epidemic waves in Jiangsu Province, Eastern China, 2013-2016

Wang Ma  1 , Haodi Huang  2 , Jian Chen  3 , Ke Xu  2 , Qigang Dai  2 , Huiyan Yu  2 , Fei Deng  2 , Xian Qi  2 , Shenjiao Wang  2 , Jie Hong  2 , Changjun Bao  2 , Xiang Huo  2 , Minghao Zhou  1   2
Affiliations

Predictors for fatal human infections with avian H7N9 influenza, evidence from four epidemic waves in Jiangsu Province, Eastern China, 2013-2016

Wang Ma et al. Influenza Other Respir Viruses. 2017 Sep.

Abstract

Background: Four epidemic waves of human infection with H7N9 have been recorded in China up to 1 June 2016, including in Jiangsu Province. However, few studies have investigated the differences in patients' characteristics among the four epidemic waves, and the analyses of factors associated with fatal infection lacked statistical power in previous studies due to limited sample size.

Methods: All laboratory-confirmed A(H7N9) patients in Jiangsu province were analysed. Patients' characteristics were compared across four waves and between survivors and those who died. Multivariate analyses were used to identify independent predictors of death.

Results: Significant differences were found in the lengths of several time intervals (from onset of disease to laboratory confirmation, to onset of ARDS and respiratory failure, and to death) and in the development of heart failure. The proportions of overweight patients and rural patients increased significantly across the four waves. Administration of glucocorticoids and double-dose neuraminidase inhibitors became the norm. Predictors of death included complications such as ARDS, heart failure and septic shock, administration of glucocorticoids, and disease duration.

Conclusion: Characteristics of H7N9 patients and clinical treatment options changed over time. Particular complications and the use of particular treatment, along with disease duration, could help clinicians predict the outcome of H7N9 infections.

Keywords: Avian influenza; H7N9; fatal infection; predictor; risk factor.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Four epidemic waves of human infections with H7N9 in Jiangsu Province, China, 2013‐2016
See this image and copyright information in PMC

References

    1. Gao R, Cao B, Hu Y, et al. Human infection with a novel avian‐origin influenza A (H7N9) virus. N Engl J Med. 2013;368:1888‐1897. - PubMed
    1. WHO . (http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IR...). Accessed August 18, 2016.
    1. Wu P, Peng Z, Fang VJ, et al. Human Infection with Influenza A(H7N9) virus during 3 major epidemic waves, China, 2013‐2015. Emerg Infect Dis. 2016;22:964‐972. - PMC - PubMed
    1. Zhou J, Wang D, Gao R, et al. Biological features of novel avian influenza A (H7N9) virus. Nature. 2013;499:500‐503. - PubMed
    1. Chen X, Yang Z, Lu Y, Xu Q, Wang Q, Chen L. Clinical features and factors associated with outcomes of patients infected with a Novel Influenza A (H7N9) virus: a preliminary study. PLoS One. 2013;8:e73362. - PMC - PubMed

MeSH terms

Substances

LinkOut - more resources