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Review
. 2017 Sep-Oct;45(5):508-518.
doi: 10.1016/j.aller.2017.05.002. Epub 2017 Jul 1.

Oral immunotherapy for food allergy: A Spanish guideline. Egg and milk immunotherapy Spanish guide (ITEMS GUIDE). Part 2: Maintenance phase of cow milk (CM) and egg oral immunotherapy (OIT), special treatment dosing schedules. Models of dosing schedules of OIT with CM and EGG

A Martorell  1 , E Alonso  2 , L Echeverría  3 , C Escudero  4 , R García-Rodríguez  5 , C Blasco  6 , J Bone  7 , J Borja-Segade  5 , T Bracamonte  3 , A Claver  8 , J L Corzo  9 , B De la Hoz  10 , R Del Olmo  11 , O Dominguez  12 , V Fuentes-Aparicio  13 , I Guallar  7 , H Larramona  14 , F Martín-Muñoz  15 , V Matheu  16 , A Michavila  17 , I Ojeda  18 , P Ojeda  18 , M Piquer  12 , P Poza  16 , M Reche  19 , P Rodríguez Del Río  4 , M Rodríguez  20 , F Ruano  21 , S Sánchez-García  4 , S Terrados  22 , L Valdesoiro  14 , M Vazquez-Ortiz  23 ; Expert panel selected from members of the Spanish Societies of Pediatric Allergology, Asthma and Clinical Immunology (SEICAP) and Allergology and Clinical Immunology (SEAIC)
Affiliations
Review

Oral immunotherapy for food allergy: A Spanish guideline. Egg and milk immunotherapy Spanish guide (ITEMS GUIDE). Part 2: Maintenance phase of cow milk (CM) and egg oral immunotherapy (OIT), special treatment dosing schedules. Models of dosing schedules of OIT with CM and EGG

A Martorell et al. Allergol Immunopathol (Madr). 2017 Sep-Oct.

Abstract

Introduction: Cow's milk and egg are the most frequent causes of food allergy in the first years of life. Treatments such as oral immunotherapy (OIT) have been investigated as an alternative to avoidance diets. No clinical practice guides on the management of OIT with milk and egg are currently available.

Objectives: To develop a clinical guide on OIT based on the available scientific evidence and the opinions of experts.

Methods: A review was made of studies published in the period between 1984 and June 2016, Doctoral Theses published in Spain, and summaries of communications at congresses (SEAIC, SEICAP, EAACI, AAAAI), with evaluation of the opinion consensus established by a group of experts pertaining to the scientific societies SEICAP and SEAIC.

Results: Recommendations have been established regarding the indications, requirements and practical aspects of the different phases of OIT, as well as special protocols for patients at high risk of suffering adverse reactions.

Conclusions: A clinical practice guide is presented for the management of OIT with milk and egg, based on the opinion consensus of Spanish experts.

Keywords: Desensitization; Egg allergy; Guide; Milk allergy; Omalizumab; Oral immunotherapy; Specific oral tolerance induction; Sublingual immunotherapy.

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