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. 2017 Jun 20:11:336.
doi: 10.3389/fnins.2017.00336. eCollection 2017.

Lower In vivo Myo-Inositol in the Anterior Cingulate Cortex Correlates with Delayed Melatonin Rhythms in Young Persons with Depression

Rébecca Robillard  1 , Jim Lagopoulos  2 , Daniel F Hermens  3 , Sharon L Naismith  3 , Naomi L Rogers  4 , Django White  3 , Joanne S Carpenter  3 , Manreena Kaur  3 , Elizabeth M Scott  3 , Ian B Hickie  3
Affiliations

Lower In vivo Myo-Inositol in the Anterior Cingulate Cortex Correlates with Delayed Melatonin Rhythms in Young Persons with Depression

Rébecca Robillard et al. Front Neurosci. .

Abstract

Myo-inositol, a second messenger glucose isomer and glial marker, is potentiated by melatonin. In addition to common abnormalities in melatonin regulation, depressive disorders have been associated with reduced myo-inositol in frontal structures. This study examined associations between myo-inositol in the anterior cingulate cortex and the timing of evening melatonin release. Forty young persons with unipolar depression were recruited from specialized mental health services (20.3 ± 3.8 years old). Healthy controls were recruited from the community (21.7 ± 2.6 years old). The timing of dim light melatonin onset (DLMO) was estimated using salivary melatonin sampling. Myo-inositol concentrations (MI/CrPCr ratio) in the anterior cingulate cortex were obtained using proton magnetic resonance spectroscopy. After controlling for age, sex, and CrPCr concentration the depression group had significantly lower MI/CrPCr ratios than healthy controls [F(4, 75) = 11.4, p = 0.001]. In the depression group, later DLMO correlated with lower MI/CrPCr ratio (r = -0.48, p = 0.014). These findings suggest that neurochemical changes in the frontal cortex are associated with circadian disruptions in young persons with depression.

Keywords: circadian; depression; magnetic resonance spectroscopy; melatonin; myo-inositol.

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Figures

Figure 1
Figure 1
Water-suppressed spectra (from the anterior cingulate cortex) processed using LCModel from two representative subjects (top panel: Control; bottom panel: Depression). Insert: Sagittal view of a representative T1-weighted image illustrating the acquisition voxel size and placement for the anterior cingulate cortex.
Figure 2
Figure 2
Correlation between DLMO (dim light melatonin onset) and myo-inositol in the depression group. MI/CrPCr ratio: myo-inositol relative to creatine ratio. The full line represents the fitted regression and dotted lines indicate the 95% confidence interval.
See this image and copyright information in PMC

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