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. 2017 Dec 15;196(12):1510-1518.
doi: 10.1164/rccm.201612-2457PP.

Extracellular Vesicle Biology in the Pathogenesis of Lung Disease

Serge P Nana-Sinkam  1 , Mario Acunzo  1 , Carlo M Croce  2 , Kai Wang  3
Affiliations

Extracellular Vesicle Biology in the Pathogenesis of Lung Disease

Serge P Nana-Sinkam et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Extracellular vesicle biogenesis. Extracellular vesicles are divided into three main types: exosomes, microvesicles, and apoptotic bodies. Exosomes are formed in multivesicular endosomes and contain molecules including nucleic acids, proteins, lipids, and metabolites. The exosomal content can be transferred to other cells through different processes, including endocytosis, phagocytosis, macropinocytosis, or direct membrane fusion.
Figure 2.
Figure 2.
Applications for extracellular vesicles in lung disease. COPD = chronic obstructive pulmonary disease; EMT = epithelial–mesenchymal transition; SOCS = suppressor of cytokine protein signaling; STAT = signal transducers and activators of transcription; TLR = Toll-like receptor.
See this image and copyright information in PMC

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